The San Francisco 49ers have a point differential of -64 points in the regular-season and playoffs against the Eagles since February 26, 1979.
| TEAM | DATE | DIFF | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/3/1983 | -5 | vs | L 17-22 | 2 | 17 | 336 | 281 | ||||
| 2 | | 49ers | 9/23/1984 | 12 | @ | W 21-9 | 3 | 23 | 398 | 241 | ||||
| 3 | | 49ers | 11/3/1985 | 11 | vs | W 24-13 | 3 | 24 | 364 | 427 | ||||
| 4 | | 49ers | 9/24/1989 | 10 | @ | W 38-28 | 5 | 19 | 444 | 315 | ||||
| 5 | | 49ers | 10/27/1991 | 16 | @ | W 23-7 | 2 | 14 | 222 | 235 | 46.7 | |||
| 6 | | 49ers | 11/29/1992 | 6 | vs | W 20-14 | 2 | 18 | 425 | 280 | 23.1 | 100.0 | ||
| 7 | | 49ers | 1/3/1994 | -3 | vs | L 34-37 | 4 | 31 | 477 | 381 | 30.8 | 100.0 | ||
| 8 | | 49ers | 10/2/1994 | -32 | vs | L 8-40 | 1 | 11 | 189 | 437 | 33.3 | 66.7 | ||
| 9 | | 49ers | 12/29/1996 | 14 | vs | W 14-0 | 2 | 17 | 279 | 283 | 50.0 | 0.0 | ||
| 10 | | 49ers | 11/10/1997 | 12 | @ | W 24-12 | 3 | 13 | 213 | 257 | 43.8 | |||
| 11 | | 49ers | 12/22/2001 | 10 | vs | W 13-3 | 1 | 14 | 244 | 292 | 33.3 | |||
| 12 | | 49ers | 11/25/2002 | -21 | vs | L 17-38 | 2 | 24 | 409 | 343 | 45.0 | 25.0 | ||
| 13 | | 49ers | 12/21/2003 | 3 | @ | W 31-28 | 3 | 22 | 414 | 293 | 42.9 | 0.0 | ||
| 14 | | 49ers | 9/18/2005 | -39 | @ | L 3-42 | 0 | 8 | 142 | 583 | 25.0 | |||
| 15 | | 49ers | 9/24/2006 | -14 | vs | L 24-38 | 3 | 23 | 392 | 416 | 38.9 | 100.0 | ||
| 16 | | 49ers | 10/12/2008 | -14 | vs | L 26-40 | 2 | 14 | 306 | 383 | 16.7 | 100.0 | ||
| 17 | | 49ers | 12/20/2009 | -14 | @ | L 13-27 | 1 | 13 | 261 | 422 | 0.0 | 75.0 | ||
| 18 | | 49ers | 10/10/2010 | -3 | vs | L 24-27 | 3 | 21 | 364 | 352 | 61.5 | |||
| 19 | | 49ers | 10/2/2011 | 1 | @ | W 24-23 | 3 | 22 | 442 | 513 | 41.7 | |||
| 20 | | 49ers | 9/28/2014 | 5 | vs | W 26-21 | 2 | 20 | 407 | 213 | 42.1 | |||
| 21 | | 49ers | 10/29/2017 | -23 | @ | L 10-33 | 1 | 14 | 238 | 304 | 20.0 | |||
| 22 | | 49ers | 10/4/2020 | -5 | vs | L 20-25 | 3 | 25 | 417 | 267 | 45.5 | 0.0 | ||
| 23 | | 49ers | 9/19/2021 | 6 | @ | W 17-11 | 2 | 23 | 306 | 328 | 42.9 | 100.0 | ||
| 24 | | 49ers | 1/29/2023 | -24 | @ | L 7-31 | 1 | 11 | 164 | 269 | 25.0 | 0.0 | ||
| 25 | | 49ers | 12/3/2023 | 23 | @ | W 42-19 | 6 | 24 | 456 | 333 | 72.7 | 100.0 | ||
| Average | -2.5 | 2.4 | 18.7 | 333.5 | 336.7 | |||||||||
| Total | -64 | 63 | 485 | 8,670 | 8,755 | |||||||||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |