49ers record all-time against afc south

The San Francisco 49ers are 13-12 against the AFC South all-time.

		TEAM	DATE	REC	TM		OPP	RESULT	W%	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1		49ers	10/9/2005	0-1	SF	vs	IND	L 3-28	.000	0	12	177	365	21.4	100.0
2		49ers	11/27/2005	0-1	SF	@	TEN	L 22-33	.000	3	15	261	461	20.0	100.0
3		49ers	12/18/2005	0-1	SF	@	JAX	L 9-10	.000	0	11	217	336	7.7	0.0
4		49ers	1/1/2006	1-0	SF	vs	HOU	W 20-17	1.000	2	19	324	284	36.8
5		49ers	10/25/2009	0-1	SF	@	HOU	L 21-24	.000	3	17	297	336	36.4	0.0
6		49ers	11/1/2009	0-1	SF	@	IND	L 14-18	.000	2	16	295	410	20.0
7		49ers	11/8/2009	0-1	SF	vs	TEN	L 27-34	.000	3	25	358	315	30.8	100.0
8		49ers	11/29/2009	1-0	SF	vs	JAX	W 20-3	1.000	2	15	284	357	50.0	100.0
9		49ers	9/22/2013	0-1	SF	vs	IND	L 7-27	.000	1	14	254	336	25.0	100.0
10		49ers	10/6/2013	1-0	SF	vs	HOU	W 34-3	1.000	4	17	284	313	36.4	0.0
11		49ers	10/20/2013	1-0	SF	@	TEN	W 31-17	1.000	4	19	349	368	50.0
12		49ers	10/27/2013	1-0	SF	@	JAX	W 42-10	1.000	6	25	398	318	66.7	100.0
13		49ers	10/8/2017	0-1	SF	@	IND	L 23-26	.000	2	23	402	447	28.6	100.0
14		49ers	12/10/2017	1-0	SF	@	HOU	W 26-16	1.000	2	20	416	311	18.2
15		49ers	12/17/2017	1-0	SF	vs	TEN	W 25-23	1.000	1	23	414	328	50.0
16		49ers	12/24/2017	1-0	SF	vs	JAX	W 44-33	1.000	6	26	369	472	66.7
17		49ers	10/24/2021	0-1	SF	vs	IND	L 18-30	.000	2	13	280	295	9.1
18		49ers	11/21/2021	1-0	SF	@	JAX	W 30-10	1.000	3	25	333	200	50.0	100.0
19		49ers	12/23/2021	0-1	SF	@	TEN	L 17-20	.000	2	22	389	278	37.5	50.0
20		49ers	1/2/2022	1-0	SF	vs	HOU	W 23-7	1.000	2	19	416	222	38.5	0.0
21		49ers	11/12/2023	1-0	SF	@	JAX	W 34-3	1.000	4	20	437	221	33.3	50.0
22		49ers	9/28/2025	0-1	SF	vs	JAX	L 21-26	.000	2	22	389	325	61.5	0.0
23		49ers	10/26/2025	0-1	SF	@	HOU	L 15-26	.000	2	12	223	475	33.3	0.0
24		49ers	12/14/2025	1-0	SF	vs	TEN	W 37-24	1.000	4	28	430	306	60.0	100.0
25		49ers	12/22/2025	1-0	SF	@	IND	W 48-27	1.000	6	28	440	312	63.6	100.0
		Average							.520	2.7	19.4	337.4	335.6	38.5	3.6
		Total		13-12					.520	68	486	8,436	8,391	38.5	64.3

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More 49ers Stats

PASS

2,167

Purdy

Brock Purdy

RUSH

1,202

McCaffrey

Christian McCaffrey

REC

924

McCaffrey

Christian McCaffrey

PPG

25.7

10th

OPP PPG

21.8

13th

RUSH YDS/G

106.9

24th

PASS YDS/G

254.0

6th

2025 Division Standings

TEAM	W	L	T	PCT
Seahawks	14	3	0	.824
Rams	12	5	0	.706
49ers	12	5	0	.706
Cardinals	3	14	0	.176

DATE	MATCHUP			TIME (ET)
Sun 1/11	SF	@	PHI	4:30 PM

SEA

14 - 3

13

Final

3

12 - 5

Sat 3 Jan 2026

NFL 2025 Leaders

Pass Yards Leaders

4,707

Stafford

Matthew Stafford

4,564

Goff

Jared Goff

4,552

Prescott

Dak Prescott

Rush Yards Leaders

1,621

Cook

James Cook III

1,595

Henry

Derrick Henry

1,585

Taylor

Jonathan Taylor

Rec Yards Leaders

1,793

Smith-Njigba

Jaxon Smith-Njigba

1,715

Nacua

Puka Nacua

1,429

Pickens

George Pickens

Pass TD Leaders

46

Stafford

Matthew Stafford

34

Goff

Jared Goff

31

Maye

Drake Maye

Rush TD Leaders

18

Taylor

Jonathan Taylor

16

Henry

Derrick Henry

14

Allen

Josh Allen

14

Adams

Davante Adams

11

McBride

Trey McBride

11

St. Brown

Amon-Ra St. Brown

QB Rating Leaders

113.5

Maye

Drake Maye

109.2

Stafford

Matthew Stafford

105.5

Goff

Jared Goff

23.0

Garrett

Myles Garrett

16.5

Burns

Brian Burns

15.0

Hunter

Danielle Hunter

NFL 2025 Rankings

30.5

28.8

28.4

28.3

28.3

27.9

Opp PPG Rankings

17.2

17.4

18.3

18.8

19.1

19.3

Total Yards Rankings

394.6

391.9

379.4

376.3

373.2

369.5

Rush Yards Rankings

159.6

156.6

144.5

134.7

129.1

128.9

Pass Yards Rankings

278.5

276.9

268.6

262.3

256.1

254.0

68.0

57.0

53.0

49.0

49.0

48.0

NFL Fantasy 2025

Fantasy RB Rankings

316.3

Taylor

Jonathan Taylor

314.6

McCaffrey

Christian McCaffrey

291.8

Robinson

Bijan Robinson

Fantasy WR Rankings

246

Nacua

Puka Nacua

240.9

Smith-Njigba

Jaxon Smith-Njigba

207

St. Brown

Amon-Ra St. Brown

Fantasy TE Rankings

189.9

McBride

Trey McBride

125.1

Goedert

Dallas Goedert

122.8

Pitts

Kyle Pitts Sr.

Fantasy K Rankings

202

Myers

Jason Myers

194

Fairbairn

Ka'imi Fairbairn

187.6

Aubrey

Brandon Aubrey

NFL 2025 Betting

Best Record ATS

12-5

12-5

12-5

12-5

11-6

10-6-1

Worst Record ATS

5-12

5-11-1

6-11

6-11

6-11

7-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176

NFL 2025 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Sat 10/4	TEN	@	ARI	22-21
Sat 10/4	TB	@	SEA	38-35
Sat 10/4	DET	@	CIN	37-24
Sat 10/4	WAS	@	LAC	27-10
Sat 10/4	NE	@	BUF	23-20

Schedule

DATE	MATCHUP			TIME (ET)
Sat 1/10	LAR	@	CAR	4:30 PM
Sat 1/10	GB	@	CHI	8:00 PM
Sun 1/11	BUF	@	JAX	1:00 PM
Sun 1/11	SF	@	PHI	4:30 PM
Sun 1/11	LAC	@	NE	8:00 PM