The San Francisco 49ers are 3-7 in the regular-season and playoffs against the Chiefs since December 15, 1997.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/12/2000 | 1-0 | vs | W 21-7 | 1.000 | 3 | 25 | 389 | 294 | 50.0 | |||
| 2 | | 49ers | 11/10/2002 | 1-0 | vs | W 17-13 | 1.000 | 2 | 22 | 323 | 256 | 61.1 | 100.0 | ||
| 3 | | 49ers | 10/1/2006 | 0-1 | @ | L 0-41 | .000 | 0 | 10 | 165 | 333 | 23.1 | |||
| 4 | | 49ers | 9/26/2010 | 0-1 | @ | L 10-31 | .000 | 1 | 11 | 251 | 457 | 23.5 | 66.7 | ||
| 5 | | 49ers | 10/5/2014 | 1-0 | vs | W 22-17 | 1.000 | 1 | 22 | 357 | 265 | 37.5 | 100.0 | ||
| 6 | | 49ers | 9/23/2018 | 0-1 | @ | L 27-38 | .000 | 3 | 26 | 406 | 384 | 22.2 | 100.0 | ||
| 7 | | 49ers | 2/2/2020 | 0-1 | @ | L 20-31 | .000 | 2 | 21 | 351 | 397 | 37.5 | 0.0 | ||
| 8 | | 49ers | 10/23/2022 | 0-1 | vs | L 23-44 | .000 | 2 | 25 | 444 | 529 | 57.1 | |||
| 9 | | 49ers | 2/11/2024 | 0-1 | @ | L 22-25 | .000 | 2 | 23 | 382 | 455 | 25.0 | 100.0 | ||
| 10 | | 49ers | 10/20/2024 | 0-1 | vs | L 18-28 | .000 | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| Average | .300 | 1.8 | 20.4 | 337.8 | 369.9 | 36.9 | 11.4 | ||||||||
| Total | 3-7 | .300 | 18 | 204 | 3,378 | 3,699 | 36.9 | 80.0 |
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
12th
RUSH YDS/G
106.9
25th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 5 | 0 | .688 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 4 | 12 | 0 | .250 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 5 | 0 | .688 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 8 | 8 | 0 | .500 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 49ers - w | 12 | 5 | 0 | .706 |
 Rams - w | 11 | 5 | 0 | .688 |
 Cardinals - e | 3 | 13 | 0 | .188 |
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 13 | 3 | 0 | .813 |
 Bills - w | 11 | 5 | 0 | .688 |
 Dolphins - e | 7 | 9 | 0 | .438 |
 Jets - e | 3 | 13 | 0 | .188 |
| AFC North | W | L | T | PCT |
9 | 7 | 0 | .563 | |
8 | 8 | 0 | .500 | |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - y | 13 | 3 | 0 | .813 |
 Chargers - w | 11 | 5 | 0 | .688 |
 Chiefs - e | 6 | 10 | 0 | .375 |
 Raiders - e | 2 | 14 | 0 | .125 |
Steelers
Ravens
