The San Francisco 49ers have a 24-10 record against the NFC in the regular-season and playoffs at home since January 22, 2021.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/26/2021 | 0-1 | vs | L 28-30 | .000 | 4 | 26 | 298 | 353 | 63.6 | |||
| 2 | | 49ers | 10/3/2021 | 0-1 | vs | L 21-28 | .000 | 3 | 23 | 457 | 234 | 14.3 | 75.0 | ||
| 3 | | 49ers | 11/7/2021 | 0-1 | vs | L 17-31 | .000 | 2 | 22 | 337 | 437 | 40.0 | |||
| 4 | | 49ers | 11/15/2021 | 1-0 | vs | W 31-10 | 1.000 | 4 | 20 | 335 | 278 | 57.1 | 50.0 | ||
| 5 | | 49ers | 11/28/2021 | 1-0 | vs | W 34-26 | 1.000 | 4 | 23 | 423 | 323 | 41.7 | |||
| 6 | | 49ers | 12/19/2021 | 1-0 | vs | W 31-13 | 1.000 | 4 | 23 | 397 | 275 | 54.5 | |||
| 7 | | 49ers | 9/18/2022 | 1-0 | vs | W 27-7 | 1.000 | 3 | 25 | 373 | 216 | 40.0 | 66.7 | ||
| 8 | | 49ers | 10/3/2022 | 1-0 | vs | W 24-9 | 1.000 | 3 | 13 | 327 | 257 | 41.7 | 0.0 | ||
| 9 | | 49ers | 11/27/2022 | 1-0 | vs | W 13-0 | 1.000 | 1 | 21 | 317 | 260 | 38.5 | 50.0 | ||
| 10 | | 49ers | 12/11/2022 | 1-0 | vs | W 35-7 | 1.000 | 5 | 24 | 404 | 322 | 44.4 | 50.0 | ||
| 11 | | 49ers | 12/24/2022 | 1-0 | vs | W 37-20 | 1.000 | 4 | 14 | 371 | 349 | 36.4 | 50.0 | ||
| 12 | | 49ers | 1/8/2023 | 1-0 | vs | W 38-13 | 1.000 | 5 | 21 | 311 | 255 | 46.2 | 0.0 | ||
| 13 | | 49ers | 1/14/2023 | 1-0 | vs | W 41-23 | 1.000 | 4 | 24 | 505 | 332 | 54.5 | |||
| 14 | | 49ers | 1/22/2023 | 1-0 | vs | W 19-12 | 1.000 | 1 | 21 | 312 | 282 | 50.0 | |||
| 15 | | 49ers | 9/21/2023 | 1-0 | vs | W 30-12 | 1.000 | 3 | 26 | 441 | 150 | 56.3 | |||
| 16 | | 49ers | 10/1/2023 | 1-0 | vs | W 35-16 | 1.000 | 5 | 30 | 395 | 362 | 60.0 | 100.0 | ||
| 17 | | 49ers | 10/8/2023 | 1-0 | vs | W 42-10 | 1.000 | 6 | 25 | 421 | 197 | 54.5 | 0.0 | ||
| 18 | | 49ers | 11/19/2023 | 1-0 | vs | W 27-14 | 1.000 | 3 | 22 | 420 | 287 | 40.0 | 0.0 | ||
| 19 | | 49ers | 12/10/2023 | 1-0 | vs | W 28-16 | 1.000 | 4 | 19 | 527 | 324 | 54.5 | |||
| 20 | | 49ers | 1/7/2024 | 0-1 | vs | L 20-21 | .000 | 3 | 20 | 300 | 258 | 50.0 | 100.0 | ||
| 21 | | 49ers | 1/20/2024 | 1-0 | vs | W 24-21 | 1.000 | 3 | 19 | 356 | 330 | 62.5 | |||
| 22 | | 49ers | 1/28/2024 | 1-0 | vs | W 34-31 | 1.000 | 4 | 23 | 413 | 442 | 50.0 | 0.0 | ||
| 23 | | 49ers | 10/6/2024 | 0-1 | vs | L 23-24 | .000 | 2 | 22 | 384 | 358 | 54.5 | 0.0 | ||
| 24 | | 49ers | 10/27/2024 | 1-0 | vs | W 30-24 | 1.000 | 3 | 19 | 469 | 292 | 50.0 | 0.0 | ||
| 25 | | 49ers | 11/17/2024 | 0-1 | vs | L 17-20 | .000 | 2 | 21 | 277 | 289 | 63.6 | |||
| Average | .706 | 3.2 | 21.7 | 375.6 | 304.4 | 47.7 | 0.0 | ||||||||
| Total | 24-10 | .706 | 110 | 738 | 12,769 | 10,349 | 47.7 | 51.4 | |||||||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |