The San Francisco 49ers have a record of 20-7 in the regular-season and playoffs versus the Lions since October 23, 1977.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/23/1977 | 1-0 | vs | W 28-7 | 1.000 | 4 | 16 | 300 | 119 | ||||
| 2 | | 49ers | 12/17/1978 | 0-1 | @ | L 14-33 | .000 | 2 | 20 | 369 | 221 | ||||
| 3 | | 49ers | 11/2/1980 | 0-1 | @ | L 13-17 | .000 | 1 | 13 | 241 | 411 | ||||
| 4 | | 49ers | 9/6/1981 | 0-1 | @ | L 17-24 | .000 | 2 | 19 | 297 | 295 | ||||
| 5 | | 49ers | 12/31/1983 | 1-0 | vs | W 24-23 | 1.000 | 3 | 20 | 291 | 412 | ||||
| 6 | | 49ers | 9/2/1984 | 1-0 | @ | W 30-27 | 1.000 | 3 | 24 | 298 | 298 | ||||
| 7 | | 49ers | 10/20/1985 | 0-1 | @ | L 21-23 | .000 | 3 | 21 | 304 | 292 | ||||
| 8 | | 49ers | 10/2/1988 | 1-0 | vs | W 20-13 | 1.000 | 2 | 19 | 339 | 297 | ||||
| 9 | | 49ers | 10/20/1991 | 1-0 | vs | W 35-3 | 1.000 | 5 | 29 | 505 | 207 | 80.0 | 100.0 | ||
| 10 | | 49ers | 12/28/1992 | 1-0 | vs | W 24-6 | 1.000 | 3 | 22 | 361 | 227 | 54.5 | 0.0 | ||
| 11 | | 49ers | 12/19/1993 | 1-0 | @ | W 55-17 | 1.000 | 7 | 26 | 565 | 288 | 71.4 | 100.0 | ||
| 12 | | 49ers | 10/9/1994 | 1-0 | @ | W 27-21 | 1.000 | 4 | 20 | 233 | 340 | 69.2 | |||
| 13 | | 49ers | 9/25/1995 | 0-1 | @ | L 24-27 | .000 | 3 | 23 | 416 | 316 | 61.5 | 100.0 | ||
| 14 | | 49ers | 12/23/1996 | 1-0 | vs | W 24-14 | 1.000 | 3 | 18 | 281 | 277 | 54.5 | |||
| 15 | | 49ers | 12/14/1998 | 1-0 | vs | W 35-13 | 1.000 | 5 | 29 | 409 | 380 | 66.7 | 100.0 | ||
| 16 | | 49ers | 11/4/2001 | 1-0 | vs | W 21-13 | 1.000 | 3 | 27 | 427 | 131 | 53.8 | 100.0 | ||
| 17 | | 49ers | 10/5/2003 | 1-0 | vs | W 24-17 | 1.000 | 3 | 20 | 325 | 305 | 40.0 | |||
| 18 | | 49ers | 11/12/2006 | 1-0 | @ | W 19-13 | 1.000 | 1 | 17 | 315 | 251 | 52.6 | |||
| 19 | | 49ers | 9/21/2008 | 1-0 | vs | W 31-13 | 1.000 | 4 | 25 | 370 | 240 | 38.5 | 100.0 | ||
| 20 | | 49ers | 12/27/2009 | 1-0 | vs | W 20-6 | 1.000 | 2 | 13 | 310 | 289 | 29.4 | 50.0 | ||
| 21 | | 49ers | 10/16/2011 | 1-0 | @ | W 25-19 | 1.000 | 2 | 14 | 314 | 310 | 14.3 | 100.0 | ||
| 22 | | 49ers | 9/16/2012 | 1-0 | vs | W 27-19 | 1.000 | 3 | 24 | 349 | 296 | 36.4 | |||
| 23 | | 49ers | 12/27/2015 | 0-1 | @ | L 17-32 | .000 | 2 | 20 | 322 | 371 | 11.1 | 0.0 | ||
| 24 | | 49ers | 9/16/2018 | 1-0 | vs | W 30-27 | 1.000 | 3 | 23 | 346 | 427 | 27.3 | |||
| 25 | | 49ers | 9/12/2021 | 1-0 | @ | W 41-33 | 1.000 | 5 | 21 | 442 | 430 | 33.3 | |||
| Average | .741 | 3.2 | 21.3 | 356.2 | 307.8 | ||||||||||
| Total | 20-7 | .741 | 87 | 575 | 9,617 | 8,311 | |||||||||
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |