The Buffalo Bills had their highest over/under line in a home game against the Seahawks on November 8, 2020, at 55 points.
| TEAM | DATE | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 11/8/2020 |  BUF | +147 | vs |  SEA | -176 | W 44-34 | +3 | +13 (Y) | 55 | +23 (O) | 5 | 27 | 420 | 419 | 41.7 | |
| 2 | | Bills | 10/19/2020 | BUF | +204 | vs |  KC | -246 | L 17-26 | +5.5 | -3.5 (N) | 54.5 | -11.5 (U) | 2 | 20 | 206 | 466 | 44.4 | |
| 3 | | Bills | 9/25/2011 | BUF | +280 | vs |  NE | -340 | W 34-31 | +7 | +10 (Y) | 54 | +11 (O) | 4 | 24 | 448 | 495 | 36.4 | 0.0 |
| 4 | | Bills | 10/9/2011 | BUF | +150 | vs |  PHI | -170 | W 31-24 | +3 | +10 (Y) | 53 | +2 (O) | 4 | 21 | 331 | 489 | 42.9 | |
| 5 | | Bills | 10/6/2002 | BUF | vs |  OAK | L 31-49 | +3 | -15 (N) | 53 | +27 (O) | 4 | 29 | 479 | 495 | 46.7 | 100.0 | ||
| 6 | | Bills | 11/2/2025 | BUF | +115 | vs | KC | -136 | W 28-21 | +2.5 | +9.5 (Y) | 52.5 | -3.5 (U) | 4 | 23 | 404 | 305 | 58.3 | 0.0 |
| 7 | | Bills | 9/7/2025 | BUF | +102 | vs |  BAL | -122 | W 41-40 | +1.5 | +2.5 (Y) | 52.5 | +28.5 (O) | 5 | 29 | 497 | 432 | 46.7 | 100.0 |
| 8 | | Bills | 1/19/2025 | BUF | +104 | vs | BAL | -123 | W 27-25 | +1.5 | +3.5 (Y) | 52.5 | -0.5 (U) | 3 | 20 | 273 | 416 | 45.5 | 100.0 |
| 9 | | Bills | 10/1/2023 | BUF | -150 | vs |  MIA | +127 | W 48-20 | -3 | +25 (Y) | 52.5 | +15.5 (O) | 6 | 24 | 414 | 393 | 50.0 | |
| 10 | | Bills | 1/9/2021 | BUF | -347 | vs |  IND | +278 | W 27-24 | -7 | -4 (N) | 51 | 0 (P) | 3 | 22 | 397 | 472 | 22.2 | |
| 11 | | Bills | 11/29/2020 | BUF | -217 | vs |  LAC | +180 | W 27-17 | -4 | +6 (Y) | 51 | -7 (U) | 3 | 23 | 332 | 367 | 44.4 | |
| 12 | | Bills | 9/27/2009 | BUF | +225 | vs |  NO | -265 | L 7-27 | +6 | -14 (N) | 51 | -17 (U) | 1 | 13 | 243 | 378 | 14.3 | 50.0 |
| 13 | | Bills | 9/18/2025 | BUF | -787 | vs | MIA | +548 | W 31-21 | -11.5 | -1.5 (N) | 50.5 | +1.5 (O) | 4 | 23 | 360 | 276 | 54.5 | |
| 14 | | Bills | 11/20/2022 | BUF | -367 | vs |  CLE | +290 | W 31-23 | -7.5 | +0.5 (Y) | 50.5 | +3.5 (O) | 2 | 22 | 357 | 396 | 27.3 | |
| 15 | | Bills | 9/8/2013 | BUF | +400 | vs | NE | -500 | L 21-23 | +10 | +8 (Y) | 50.5 | -6.5 (U) | 3 | 15 | 286 | 431 | 30.8 | |
| 16 | | Bills | 1/16/2021 | BUF | -139 | vs | BAL | +117 | W 17-3 | -2.5 | +11.5 (Y) | 50 | -30 (U) | 2 | 17 | 220 | 340 | 30.8 | |
| 17 | | Bills | 12/14/2014 | BUF | +160 | vs |  GB | -185 | W 21-13 | +4 | +12 (Y) | 50 | -16 (U) | 1 | 13 | 253 | 333 | 25.0 | |
| 18 | | Bills | 10/21/1991 | BUF | vs |  CIN | W 35-16 | -13.5 | +5.5 (Y) | 50 | +1 (O) | 5 | 19 | 487 | 411 | 72.7 | |||
| 19 | | Bills | 1/12/2025 | BUF | -426 | vs |  DEN | +328 | W 31-7 | -7.5 | +16.5 (Y) | 49.5 | -11.5 (U) | 3 | 26 | 471 | 224 | 53.3 | 100.0 |
| 20 | | Bills | 11/21/2021 | BUF | -310 | vs | IND | +244 | L 15-41 | -7 | -33 (N) | 49.5 | +6.5 (O) | 2 | 19 | 311 | 370 | 50.0 | |
| 21 | | Bills | 10/27/2002 | BUF | vs |  DET | W 24-17 | -7 | 0 (P) | 49.5 | -8.5 (U) | 3 | 23 | 343 | 282 | 42.9 | 100.0 | ||
| 22 | | Bills | 11/3/2024 | BUF | -279 | vs | MIA | +225 | W 30-27 | -6 | -3 (N) | 49 | +8 (O) | 3 | 24 | 325 | 373 | 50.0 | 100.0 |
| 23 | | Bills | 12/17/2023 | BUF | -139 | vs |  DAL | +117 | W 31-10 | -2.5 | +18.5 (Y) | 49 | -8 (U) | 4 | 28 | 351 | 195 | 55.6 | |
| 24 | | Bills | 12/3/2017 | BUF | +305 | vs | NE | -335 | L 3-23 | +7.5 | -12.5 (N) | 49 | -23 (U) | 0 | 16 | 268 | 435 | 38.5 | 0.0 |
| 25 | | Bills | 1/30/1994 | BUF | vs | DAL | L 13-30 | +10.5 | -6.5 (N) | 49 | -6 (U) | 1 | 22 | 314 | 341 | 29.4 | 66.7 | ||
Results may be incomplete. StatMuse has complete team, game-level data for over/under lines going back to the 1979 season.
More Bills Stats
Team Rankings
PPG
29.4
3rd
OPP PPG
20.9
9th
RUSH YDS/G
161.5
1st
PASS YDS/G
235.9
14th
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