The Los Angeles Chargers have a 25-15-2 record against the Bills in the regular season and playoffs all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Chargers | 10/2/1960 | 1-0 | @ | W 24-10 | 1.000 | 3 | 12 | 159 | 238 | ||||
| 2 | | Chargers | 11/20/1960 | 0-1 | vs | L 3-32 | .000 | 0 | 11 | 185 | 248 | ||||
| 3 | | Chargers | 9/30/1961 | 1-0 | @ | W 19-11 | 1.000 | 2 | 15 | 302 | 239 | ||||
| 4 | | Chargers | 12/10/1961 | 1-0 | vs | W 28-10 | 1.000 | 4 | 7 | 237 | 279 | ||||
| 5 | | Chargers | 10/13/1962 | 0-1 | @ | L 10-35 | .000 | 1 | 12 | 115 | 439 | ||||
| 6 | | Chargers | 11/11/1962 | 0-1 | vs | L 20-40 | .000 | 3 | 21 | 370 | 335 | ||||
| 7 | | Chargers | 9/8/1963 | 1-0 | vs | W 14-10 | 1.000 | 2 | 17 | 370 | 306 | ||||
| 8 | | Chargers | 11/17/1963 | 1-0 | @ | W 23-13 | 1.000 | 2 | 16 | 355 | 358 | ||||
| 9 | | Chargers | 9/26/1964 | 0-1 | @ | L 3-30 | .000 | 0 | 15 | 248 | 272 | ||||
| 10 | | Chargers | 11/26/1964 | 0-1 | vs | L 24-27 | .000 | 3 | 11 | 334 | 273 | ||||
| 11 | | Chargers | 12/26/1964 | 0-1 | @ | L 7-20 | .000 | 1 | 15 | 259 | 387 | ||||
| 12 | | Chargers | 10/10/1965 | 1-0 | @ | W 34-3 | 1.000 | 4 | 18 | 458 | 150 | ||||
| 13 | | Chargers | 11/25/1965 | 0-0-1 | vs | T 20-20 | .500 | 2 | 23 | 361 | 241 | ||||
| 14 | | Chargers | 12/26/1965 | 0-1 | vs | L 0-23 | .000 | 0 | 12 | 223 | 260 | ||||
| 15 | | Chargers | 9/4/1966 | 1-0 | vs | W 27-7 | 1.000 | 3 | 15 | 290 | 267 | ||||
| 16 | | Chargers | 10/16/1966 | 0-0-1 | @ | T 17-17 | .500 | 2 | 12 | 219 | 320 | ||||
| 17 | | Chargers | 10/1/1967 | 1-0 | @ | W 37-17 | 1.000 | 4 | 26 | 484 | 247 | ||||
| 18 | | Chargers | 11/17/1968 | 1-0 | @ | W 21-6 | 1.000 | 3 | 15 | 282 | 151 | ||||
| 19 | | Chargers | 12/14/1969 | 1-0 | vs | W 45-6 | 1.000 | 6 | 30 | 537 | 238 | ||||
| 20 | | Chargers | 10/23/1971 | 1-0 | vs | W 20-3 | 1.000 | 2 | 22 | 446 | 189 | ||||
| 21 | | Chargers | 9/23/1973 | 1-0 | vs | W 34-7 | 1.000 | 5 | 17 | 354 | 287 | ||||
| 22 | | Chargers | 11/21/1976 | 1-0 | @ | W 34-13 | 1.000 | 4 | 20 | 382 | 219 | ||||
| 23 | | Chargers | 9/16/1979 | 1-0 | vs | W 27-19 | 1.000 | 4 | 18 | 339 | 298 | ||||
| 24 | | Chargers | 10/5/1980 | 0-1 | vs | L 24-26 | .000 | 3 | 19 | 300 | 202 | ||||
| 25 | | Chargers | 1/3/1981 | 1-0 | vs | W 20-14 | 1.000 | 2 | 21 | 397 | 244 | ||||
| Average | .619 | 2.7 | 18.1 | 331.1 | 291.9 | ||||||||||
| Total | 25-15-2 | .619 | 115 | 761 | 13,905 | 12,258 | |||||||||
LAC
BUFMore NFL News
Ravens responded again under pressure to improve to 4-1 despite injuries
Caleb Williams close to returning after rough performance for Bears quarterbacks
Mike McCarthy’s sideline call for Patrick Graham shows the 'pliable' nature of the Steelers staff
Cowboys add Mike Pettine to staff after rough start for new defensive coordinator Christian Parker
Falcons are facing more quarterback uncertainty after Penix injures rib in overtime loss
Packers' Love reaps the benefits as Watson and Golden develop into dynamic receiving duo
More Chargers Stats
Team Leaders 
PASS
937
Herbert
RUSH
271
Hampton
REC
225
Harris
Team Rankings
PPG
16.8
30th
OPP PPG
25.8
22nd
RUSH YDS/G
128.2
9th
PASS YDS/G
187.4
29th
Chiefs
Broncos
Raiders
LAR
HOU
BAL
NYJ
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Cowboys
Commanders
Vikings
Packers
Lions
Bears
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Patriots
Dolphins
Browns
Steelers
Bengals
Jaguars
Colts
Titans