Emmitt Smith has the most career carries, with 4,409 carries.

highest+career+100+*+(rush++ td+/+rush++ att)+by+a+player+with+25+or+more+rush++ td
Interpreted as:
highest+career+100+*+(rush++ rushing td+/+rush++ rushing att)+by+a+player+with+25+or+more+rush++ rushing td

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