The Detroit Lions have a 20-28-1 record in the regular-season and playoffs against the 49ers since March 21, 1960.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Lions | 10/9/1960 | 0-1 |  DET | vs |  SF | L 10-14 | .000 | 1 | 13 | 232 | 283 | ||
| 2 | | Lions | 11/6/1960 | 1-0 | DET | @ | SF | W 24-0 | 1.000 | 3 | 15 | 313 | 232 | ||
| 3 | | Lions | 10/1/1961 | 0-1 | DET | vs | SF | L 0-49 | .000 | 0 | 16 | 291 | 317 | ||
| 4 | | Lions | 11/5/1961 | 0-0-1 | DET | @ | SF | T 20-20 | .500 | 2 | 22 | 402 | 326 | ||
| 5 | | Lions | 9/23/1962 | 1-0 | DET | vs | SF | W 45-24 | 1.000 | 6 | 22 | 424 | 342 | ||
| 6 | | Lions | 11/11/1962 | 1-0 | DET | @ | SF | W 38-24 | 1.000 | 5 | 21 | 437 | 288 | ||
| 7 | | Lions | 10/6/1963 | 1-0 | DET | vs | SF | W 26-3 | 1.000 | 3 | 10 | 231 | 61 | ||
| 8 | | Lions | 11/3/1963 | 1-0 | DET | @ | SF | W 45-7 | 1.000 | 6 | 27 | 509 | 133 | ||
| 9 | | Lions | 9/13/1964 | 1-0 | DET | @ | SF | W 26-17 | 1.000 | 2 | 17 | 372 | 219 | ||
| 10 | | Lions | 12/13/1964 | 1-0 | DET | vs | SF | W 24-7 | 1.000 | 3 | 12 | 327 | 287 | ||
| 11 | | Lions | 11/14/1965 | 0-1 | DET | vs | SF | L 21-27 | .000 | 3 | 17 | 193 | 324 | ||
| 12 | | Lions | 12/5/1965 | 0-1 | DET | @ | SF | L 14-17 | .000 | 2 | 16 | 300 | 357 | ||
| 13 | | Lions | 10/23/1966 | 0-1 | DET | @ | SF | L 24-27 | .000 | 3 | 17 | 314 | 359 | ||
| 14 | | Lions | 11/24/1966 | 0-1 | DET | vs | SF | L 14-41 | .000 | 2 | 10 | 196 | 487 | ||
| 15 | | Lions | 10/29/1967 | 1-0 | DET | @ | SF | W 45-3 | 1.000 | 6 | 24 | 391 | 173 | ||
| 16 | | Lions | 10/27/1968 | 0-1 | DET | vs | SF | L 7-14 | .000 | 1 | 10 | 219 | 332 | ||
| 17 | | Lions | 11/2/1969 | 1-0 | DET | @ | SF | W 26-14 | 1.000 | 2 | 12 | 125 | 282 | ||
| 18 | | Lions | 11/22/1970 | 1-0 | DET | vs | SF | W 28-7 | 1.000 | 4 | 19 | 298 | 190 | ||
| 19 | | Lions | 12/19/1971 | 0-1 | DET | @ | SF | L 27-31 | .000 | 3 | 18 | 310 | 357 | ||
| 20 | | Lions | 11/4/1973 | 1-0 | DET | vs | SF | W 30-20 | 1.000 | 3 | 18 | 391 | 324 | ||
| 21 | | Lions | 10/14/1974 | 1-0 | DET | vs | SF | W 17-13 | 1.000 | 2 | 13 | 229 | 310 | ||
| 22 | | Lions | 11/2/1975 | 1-0 | DET | @ | SF | W 28-17 | 1.000 | 4 | 17 | 286 | 296 | ||
| 23 | | Lions | 10/23/1977 | 0-1 | DET | @ | SF | L 7-28 | .000 | 1 | 16 | 119 | 300 | ||
| 24 | | Lions | 12/17/1978 | 1-0 | DET | vs | SF | W 33-14 | 1.000 | 3 | 17 | 221 | 369 | ||
| 25 | | Lions | 11/2/1980 | 1-0 | DET | vs | SF | W 17-13 | 1.000 | 2 | 21 | 411 | 241 | ||
| Average | .418 | 2.5 | 18.1 | 308.2 | 324.4 | ||||||||||
| Total | 20-28-1 | .418 | 121 | 885 | 15,101 | 15,896 | |||||||||
More Lions Stats
Team Rankings
PPG
31.8
2nd
OPP PPG
23.7
18th
RUSH YDS/G
128.7
8th
PASS YDS/G
232.2
14th
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Patriots 
Bills 
Steelers 
Bengals 
Colts 
Jaguars 
Chargers 
Broncos | NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 3 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Packers | 3 | 1 | 1 | .700 |
| Lions | 4 | 2 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 5 | 1 | 0 | .833 |
 Falcons | 3 | 2 | 0 | .600 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 2 | 0 | .667 |
 Seahawks | 4 | 2 | 0 | .667 |
DAL 
KC 
NYJ 
LV 
LAR 
TEN 
NO 
MIA 
CLE 
