The San Francisco 49ers gained their most all-purpose yards in a game against the Bills on October 7, 2012, with 621 yards.
Interpreted as:
most all purpose yards in a regular-season game on the 49ers all-time| TEAM | YDS | DATE | TM | OPP | RESULT | TD | PASS YDS | SCKY | PASS TD | RUSH YDS | RUSH TD | RET YDS | RET TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 621 | 10/7/2012 | vs | W 45-3 | 6 | 310 | 0 | 3 | 311 | 3 | 64 | 0 | ||
| 2 | | 49ers | 598 | 9/13/1992 | vs | L 31-34 | 4 | 449 | 10 | 3 | 159 | 1 | 75 | 0 | ||
| 3 | | 49ers | 597 | 12/13/1953 | vs | W 45-14 | 6 | 371 | 26 | 4 | 252 | 2 | 0 | |||
| 4 | | 49ers | 590 | 10/18/1992 | vs | W 56-17 | 8 | 399 | 0 | 3 | 191 | 5 | 38 | 0 | ||
| 5 | | 49ers | 580 | 9/25/1988 | @ | W 38-7 | 5 | 351 | 10 | 5 | 239 | 0 | 48 | 0 | ||
| 6 | | 49ers | 571 | 9/15/2019 | @ | W 41-17 | 5 | 312 | 0 | 3 | 259 | 2 | 17 | 0 | ||
| 7 | | 49ers | 565 | 12/19/1993 | @ | W 55-17 | 7 | 393 | 0 | 4 | 172 | 3 | 34 | 0 | ||
| 8 | | 49ers | 557 | 9/6/1998 | vs | W 36-30 | 5 | 363 | 13 | 3 | 207 | 2 | 129 | 0 | ||
| 9 | | 49ers | 555 | 10/15/1961 | @ | W 38-24 | 5 | 243 | 12 | 0 | 324 | 5 | 115 | 0 | ||
| 10 | | 49ers | 542 | 12/5/1999 | @ | L 30-44 | 4 | 437 | 0 | 3 | 105 | 1 | 86 | 0 | ||
| 11 | | 49ers | 539 | 11/28/1993 | @ | W 35-10 | 5 | 488 | 13 | 4 | 64 | 1 | 92 | 0 | ||
| 12 | | 49ers | 539 | 11/23/1958 | @ | W 33-12 | 4 | 283 | 0 | 3 | 256 | 1 | 0 | |||
| 13 | | 49ers | 538 | 9/27/1998 | vs | W 31-20 | 4 | 387 | 10 | 3 | 161 | 1 | 76 | 0 | ||
| 14 | | 49ers | 536 | 11/19/1961 | vs | W 41-31 | 5 | 322 | 4 | 3 | 218 | 2 | 92 | 0 | ||
| 15 | | 49ers | 534 | 9/10/1984 | vs | W 37-31 | 4 | 381 | 14 | 2 | 167 | 2 | 74 | 0 | ||
| 16 | | 49ers | 527 | 12/10/2023 | vs | W 28-16 | 4 | 368 | 14 | 2 | 173 | 2 | 69 | 0 | ||
| 17 | | 49ers | 527 | 9/18/1983 | @ | W 42-27 | 6 | 341 | 5 | 3 | 191 | 1 | 96 | 2 | ||
| 18 | | 49ers | 521 | 12/8/1984 | vs | W 51-7 | 6 | 346 | 9 | 3 | 184 | 3 | 88 | 0 | ||
| 19 | | 49ers | 521 | 10/8/1961 | vs | W 35-0 | 5 | 272 | 10 | 1 | 259 | 4 | 10 | 0 | ||
| 20 | | 49ers | 517 | 10/14/2001 | @ | W 37-31 | 5 | 332 | 2 | 3 | 187 | 2 | 153 | 0 | ||
| 21 | | 49ers | 517 | 10/21/1984 | @ | W 34-21 | 4 | 353 | 0 | 3 | 164 | 1 | 85 | 0 | ||
| 22 | | 49ers | 517 | 9/24/1967 | vs | W 38-7 | 5 | 353 | 16 | 2 | 180 | 3 | 95 | 0 | ||
| 23 | | 49ers | 516 | 12/8/2019 | @ | W 48-46 | 6 | 384 | 30 | 5 | 162 | 1 | 24 | 0 | ||
| 24 | | 49ers | 515 | 11/12/1989 | vs | W 45-3 | 6 | 286 | 6 | 3 | 235 | 2 | 127 | 1 | ||
| 25 | | 49ers | 510 | 10/3/1971 | @ | W 31-3 | 4 | 308 | 0 | 3 | 202 | 1 | 85 | 0 | ||
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More 49ers Stats
Team Leaders 
PASS
205
Purdy
RUSH
68
McCaffrey
REC
50
Robinson
Team Rankings
PPG
27.0
1st
OPP PPG
7.0
1st
RUSH YDS/G
174.0
1st
PASS YDS/G
205.0
1st
Cardinals
Rams
MIA
DEN
WAS
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC North | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC South | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 1 | 0 | .000 |
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