most sacks in a game by buffalo bills player all-time

Mario Williams has the most sacks for the Bills in a game, with 4.5 sacks versus the Panthers on September 15, 2013.

Interpreted as:
most defensive sacks in a regular-season game by buffalo bills player all-time
NAMESCKDATETMOPPTKLASTCOMBSCKYINTINT YDSINT TDFFFRFR TD
1Mario Williams
M. Williams
4.5
9/15/2013
vs
5
1
6
24.5
0
0
0
0
0
0
2Bruce Smith
B. Smith
4.0
9/18/1994
@
0
0
0
0
3Bruce Smith
B. Smith
4.0
12/9/1990
@
0
0
0
0
4Cornelius Bennett
C. Bennett
4.0
12/27/1987
@
0
0
0
0
5Mario Williams
M. Williams
3.5
11/13/2014
@
4
1
5
21
0
0
0
0
0
0
6Greg Rousseau
G. Rousseau
3.0
9/8/2024
vs
6
0
6
11
0
0
0
1
0
0
7Jordan Phillips
J. Phillips
3.0
10/6/2019
@
3
0
3
23
0
0
0
0
0
0
8Lorenzo Alexander
L. Alexander
3.0
10/9/2016
@
7
0
7
19
0
0
0
0
0
0
9Marcell Dareus
M. Dareus
3.0
11/9/2014
vs
4
3
7
15
0
0
0
0
0
0
10Marcell Dareus
M. Dareus
3.0
10/5/2014
@
5
0
5
18
0
0
0
1
0
0
11Mario Williams
M. Williams
3.0
11/25/2012
@
3
0
3
8
0
0
0
0
0
0
12Chris Kelsay
C. Kelsay
3.0
12/24/2011
vs
7
3
10
27
0
0
0
1
0
0
13Aaron Schobel
A. Schobel
3.0
12/27/2009
@
4
0
4
16
0
0
0
2
0
0
14Aaron Schobel
A. Schobel
3.0
12/10/2006
@
6
3
9
31
0
0
0
1
0
0
15Ryan Denney
R. Denney
3.0
9/17/2006
@
4
0
4
33
0
0
0
1
0
0
16Lawyer Milloy
L. Milloy
3.0
11/21/2004
vs
6
0
6
22
0
0
0
0
0
0
17Aaron Schobel
A. Schobel
3.0
11/30/2003
@
5
0
5
18
0
0
0
0
1
0
18Pat Williams
P. Williams
3.0
12/6/1998
@
0
0
0
0
19Bryce Paup
B. Paup
3.0
9/7/1997
@
0
0
0
0
20Bruce Smith
B. Smith
3.0
9/8/1996
vs
0
0
0
0
21Bruce Smith
B. Smith
3.0
12/3/1995
@
0
0
0
0
22Bryce Paup
B. Paup
3.0
11/5/1995
@
0
0
0
0
23Bryce Paup
B. Paup
3.0
9/17/1995
vs
0
0
0
0
24Bruce Smith
B. Smith
3.0
9/20/1992
vs
0
0
0
0
25Bruce Smith
B. Smith
3.0
10/22/1989
vs
0
0
0
0
StatMuse has game-level data for sacks going back to the 1982 season.

More Bills Stats

Team Leaders

PASS

3,668

Allen

Josh Allen

RUSH

1,621

Cook

James Cook III

REC

719

Shakir

Khalil Shakir
Team Rankings

PPG

28.3

4th

OPP PPG

21.5

12th

RUSH YDS/G

159.6

1st

PASS YDS/G

234.2

13th

2025 Division Standings
TEAMWLTPCT
14
3
0
.824
Bills Bills
12
5
0
.706
7
10
0
.412
3
14
0
.176
Schedule
DATEMATCHUPTIME (ET)
Sun
1/11
@
1:00 PM
Last Game
NYJ Jets

3 - 14

8

Final

35

BUF Bills

12 - 5

Sun 4 Jan 2026

NFL 2025 Leaders

NFL 2025 Rankings

NFL Fantasy 2025

NFL 2025 Betting

NFL 2025 Standings

AFC EastWLTPCT
14
3
0
.824
Bills Bills - w
12
5
0
.706
7
10
0
.412
Jets Jets - e
3
14
0
.176
AFC NorthWLTPCT
10
7
0
.588
8
9
0
.471
6
11
0
.353
5
12
0
.294
AFC SouthWLTPCT
13
4
0
.765
12
5
0
.706
Colts Colts - e
8
9
0
.471
3
14
0
.176
AFC WestWLTPCT
14
3
0
.824
11
6
0
.647
6
11
0
.353
3
14
0
.176
NFC EastWLTPCT
11
6
0
.647
7
9
1
.441
5
12
0
.294
4
13
0
.235
NFC NorthWLTPCT
Bears Bears - y
11
6
0
.647
9
7
1
.559
9
8
0
.529
Lions Lions - e
9
8
0
.529
NFC SouthWLTPCT
8
9
0
.471
8
9
0
.471
8
9
0
.471
6
11
0
.353
NFC WestWLTPCT
14
3
0
.824
Rams Rams - w
12
5
0
.706
49ers 49ers - w
12
5
0
.706
3
14
0
.176

NFL 2025 Scores & Schedule

Scores

DATEMATCHUPSCORE
Sat
10/4
@
22-21
Sat
10/4
@
38-35
Sat
10/4
@
37-24
Sat
10/4
@
27-10
Sat
10/4
@
23-20

Schedule

DATEMATCHUPTIME (ET)
Sat
1/10
@
4:30 PM
Sat
1/10
@
8:00 PM
Sun
1/11
@
1:00 PM
Sun
1/11
@
4:30 PM
Sun
1/11
@
8:00 PM