Since 2000, Ed Reed has caught the most interceptions in the regular-season and playoffs, with 73 interceptions.
Interpreted as:
NFL player most defensive interceptions since 2000, combine regular season and playoffs| NAME | INT | GP | TKL | AST | COMB | SCK | SCKY | INT YDS | INT TD | FF | FR | FR TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | E. Reed | 73 | 189 | 573 | 119 | 692 | 6.0 | 56 | 1,758 | 8 | 11 | 14 | 2 |
| 2 |  | C. Woodson | 60 | 239 | 879 | 214 | 1,093 | 21.0 | 845 | 9 | 29 | 17 | 2 | |
| 3 |  | D. Sharper | 59 | 169 | 564 | 158 | 722 | 8.5 | 1,330 | 9 | 9 | 7 | 1 | |
| 4 | | A. Samuel | 58 | 178 | 456 | 44 | 500 | 0.0 | 0 | 955 | 10 | 7 | 3 | 0 |
| 5 | | C. Bailey | 48 | 208 | 728 | 92 | 820 | 2.0 | 509 | 3 | 7 | 6 | 0 | |
| 6 | | R. Barber | 45 | 215 | 867 | 174 | 1,041 | 25.0 | 913 | 9 | 14 | 12 | 4 | |
| 7 | | D. Hall | 43 | 175 | 648 | 187 | 835 | 2.0 | 8 | 838 | 5 | 11 | 15 | 5 |
| 8 | | T. Newman | 42 | 231 | 785 | 133 | 918 | 2.0 | 6 | 363 | 3 | 8 | 11 | 1 |
| 9 |  | R. Sherman | 41 | 159 | 417 | 129 | 546 | 2.0 | 23 | 494 | 3 | 6 | 7 | 0 |
| 10 | | D. Bly | 40 | 155 | 392 | 55 | 447 | 5.0 | 599 | 4 | 20 | 12 | 2 | |
| 11 | | T. Law | 39 | 138 | 407 | 85 | 492 | 3.0 | 629 | 5 | 5 | 2 | 0 | |
| 12 | | R. Nelson | 38 | 189 | 655 | 219 | 874 | 8.5 | 70.5 | 486 | 1 | 10 | 8 | 0 |
| 13 | | T. Williams | 38 | 221 | 638 | 136 | 774 | 4.5 | 29.5 | 529 | 2 | 6 | 16 | 0 |
| 14 | | C. Tillman | 38 | 174 | 815 | 147 | 962 | 3.0 | 14 | 675 | 8 | 45 | 12 | 1 |
| 15 |  | T. Mathieu | 37 | 191 | 725 | 162 | 887 | 11.0 | 78 | 547 | 4 | 7 | 8 | 0 |
| 16 | | H. Smith | 37 | 200 | 861 | 320 | 1,181 | 21.5 | 189 | 498 | 4 | 12 | 9 | 0 |
| 17 |  | P. Peterson | 37 | 206 | 588 | 82 | 670 | 4.0 | 17 | 481 | 2 | 2 | 12 | 0 |
| 18 | | D. McCourty | 37 | 229 | 832 | 258 | 1,090 | 3.0 | 28 | 585 | 2 | 11 | 7 | 0 |
| 19 | | M. Peters | 36 | 127 | 345 | 89 | 434 | 2.0 | 22 | 940 | 7 | 12 | 10 | 1 |
| 20 | | N. Clements | 36 | 182 | 680 | 158 | 838 | 4.5 | 25 | 508 | 5 | 23 | 8 | 0 |
| 21 | | A. Talib | 35 | 159 | 425 | 83 | 508 | 1.0 | 8 | 752 | 10 | 6 | 4 | 0 |
| 22 |  | T. Polamalu | 35 | 173 | 623 | 221 | 844 | 12.5 | 78.5 | 456 | 4 | 14 | 7 | 2 |
| 23 | | T. James | 35 | 118 | 294 | 38 | 332 | 1.0 | 401 | 1 | 4 | 2 | 0 | |
| 24 | | S. Gilmore | 34 | 189 | 544 | 99 | 643 | 1.0 | 7 | 496 | 2 | 9 | 3 | 0 |
| 25 | | A. Cromartie | 34 | 173 | 414 | 45 | 459 | 0.0 | 0 | 632 | 3 | 3 | 5 | 2 |
StatMuse has season-level data for interceptions going back to the 1940 season.
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 Eagles | 14 | 3 | 0 | .824 |
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