| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/21/1980 | 0-1 |  SF | vs |  BUF | L 13-18 | .000 | 2 | 19 | 298 | 267 | ||
| 2 | | 49ers | 12/17/1989 | 1-0 | SF | vs | BUF | W 21-10 | 1.000 | 3 | 18 | 283 | 301 | ||
| 3 | | 49ers | 9/13/1992 | 0-1 | SF | vs | BUF | L 31-34 | .000 | 4 | 26 | 598 | 488 | 61.5 | 100.0 |
| 4 | | 49ers | 12/3/1995 | 1-0 | SF | vs | BUF | W 27-17 | 1.000 | 3 | 18 | 323 | 275 | 31.3 | 50.0 |
| 5 | | 49ers | 12/2/2001 | 1-0 | SF | vs | BUF | W 35-0 | 1.000 | 5 | 26 | 409 | 191 | 66.7 | 0.0 |
| 6 | | 49ers | 12/26/2004 | 0-1 | SF | vs | BUF | L 7-41 | .000 | 1 | 12 | 189 | 441 | 30.0 | 100.0 |
| 7 | | 49ers | 10/7/2012 | 1-0 | SF | vs | BUF | W 45-3 | 1.000 | 6 | 29 | 621 | 204 | 63.6 | 100.0 |
| 8 | | 49ers | 12/7/2020 | 0-1 | SF | vs | BUF | L 24-34 | .000 | 3 | 24 | 402 | 449 | 54.5 | 0.0 |
| Average | .500 | 3.4 | 21.5 | 390.4 | 327.0 | ||||||||||
| Total | 4-4 | .500 | 27 | 172 | 3,123 | 2,616 |
More 49ers Stats
Team Rankings
PPG
21.2
22nd
OPP PPG
19.6
6th
RUSH YDS/G
85.2
28th
PASS YDS/G
298.2
2nd
Rams 
Cardinals 
HOU 
NYG 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 1 | 0 | .800 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 2 | 0 | .600 |
Patriots 
Steelers 
Bengals 
Colts 
Jaguars 
Chargers 
Broncos 
DAL 
KC 
NYJ 
LV 
BAL 
CLE 
