The San Francisco 49ers have an 11-11 record against the AFC South in the regular-season and playoffs all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/9/2005 | 0-1 |  SF | vs |  IND | L 3-28 | .000 | 0 | 12 | 177 | 365 | 21.4 | 100.0 |
| 2 | | 49ers | 11/27/2005 | 0-1 | SF | @ |  TEN | L 22-33 | .000 | 3 | 15 | 261 | 461 | 20.0 | 100.0 |
| 3 | | 49ers | 12/18/2005 | 0-1 | SF | @ |  JAX | L 9-10 | .000 | 0 | 11 | 217 | 336 | 7.7 | 0.0 |
| 4 | | 49ers | 1/1/2006 | 1-0 | SF | vs |  HOU | W 20-17 | 1.000 | 2 | 19 | 324 | 284 | 36.8 | |
| 5 | | 49ers | 10/25/2009 | 0-1 | SF | @ | HOU | L 21-24 | .000 | 3 | 17 | 297 | 336 | 36.4 | 0.0 |
| 6 | | 49ers | 11/1/2009 | 0-1 | SF | @ | IND | L 14-18 | .000 | 2 | 16 | 295 | 410 | 20.0 | |
| 7 | | 49ers | 11/8/2009 | 0-1 | SF | vs | TEN | L 27-34 | .000 | 3 | 25 | 358 | 315 | 30.8 | 100.0 |
| 8 | | 49ers | 11/29/2009 | 1-0 | SF | vs | JAX | W 20-3 | 1.000 | 2 | 15 | 284 | 357 | 50.0 | 100.0 |
| 9 | | 49ers | 9/22/2013 | 0-1 | SF | vs | IND | L 7-27 | .000 | 1 | 14 | 254 | 336 | 25.0 | 100.0 |
| 10 | | 49ers | 10/6/2013 | 1-0 | SF | vs | HOU | W 34-3 | 1.000 | 4 | 17 | 284 | 313 | 36.4 | 0.0 |
| 11 | | 49ers | 10/20/2013 | 1-0 | SF | @ | TEN | W 31-17 | 1.000 | 4 | 19 | 349 | 368 | 50.0 | |
| 12 | | 49ers | 10/27/2013 | 1-0 | SF | @ | JAX | W 42-10 | 1.000 | 6 | 25 | 398 | 318 | 66.7 | 100.0 |
| 13 | | 49ers | 10/8/2017 | 0-1 | SF | @ | IND | L 23-26 | .000 | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 14 | | 49ers | 12/10/2017 | 1-0 | SF | @ | HOU | W 26-16 | 1.000 | 2 | 20 | 416 | 311 | 18.2 | |
| 15 | | 49ers | 12/17/2017 | 1-0 | SF | vs | TEN | W 25-23 | 1.000 | 1 | 23 | 414 | 328 | 50.0 | |
| 16 | | 49ers | 12/24/2017 | 1-0 | SF | vs | JAX | W 44-33 | 1.000 | 6 | 26 | 369 | 472 | 66.7 | |
| 17 | | 49ers | 10/24/2021 | 0-1 | SF | vs | IND | L 18-30 | .000 | 2 | 13 | 280 | 295 | 9.1 | |
| 18 | | 49ers | 11/21/2021 | 1-0 | SF | @ | JAX | W 30-10 | 1.000 | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 19 | | 49ers | 12/23/2021 | 0-1 | SF | @ | TEN | L 17-20 | .000 | 2 | 22 | 389 | 278 | 37.5 | 50.0 |
| 20 | | 49ers | 1/2/2022 | 1-0 | SF | vs | HOU | W 23-7 | 1.000 | 2 | 19 | 416 | 222 | 38.5 | 0.0 |
| 21 | | 49ers | 11/12/2023 | 1-0 | SF | @ | JAX | W 34-3 | 1.000 | 4 | 20 | 437 | 221 | 33.3 | 50.0 |
| 22 | | 49ers | 9/28/2025 | 0-1 | SF | vs | JAX | L 21-26 | .000 | 2 | 22 | 389 | 325 | 61.5 | 0.0 |
| Average | .500 | 2.5 | 19.0 | 333.8 | 331.7 | 36.5 | 4.3 | ||||||||
| Total | 11-11 | .500 | 56 | 418 | 7,343 | 7,298 | 36.5 | 64.0 |
More 49ers Stats
Team Rankings
PPG
21.2
21st
OPP PPG
19.6
6th
RUSH YDS/G
85.2
28th
PASS YDS/G
298.2
2nd
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 2 | 0 | .600 |
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