Since 2000-01, the Columbus Blue Jackets and the Washington Capitals are tied for the highest goal differential in a game, with a differential of 10 goals.

highest goal differential in NHL regular-season game after 2000

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
1	Blue Jackets	10	11/4/2016	CBJ	vs	MTL	W 10-0	10	0	4	5	0	1	40	30
2	Capitals	10	1/11/2003	WSH	vs	FLA	W 12-2	12	2	3	4	0	4	40	26
3	Canucks	9	11/2/2023	VAN	@	SJS	W 10-1	10	1	4	5	1	3	33	31
4	Penguins	9	3/27/2022	PIT	vs	DET	W 11-2	11	2	3	6	1	5	35	35
5	Rangers	9	3/17/2021	NYR	vs	PHI	W 9-0	9	0	1	4	0	2	29	26
6	Canadiens	9	12/2/2017	MTL	vs	DET	W 10-1	10	1	1	2	0	1	34	23
7	Blackhawks	9	10/5/2017	CHI	vs	PIT	W 10-1	10	1	0	6	1	2	44	29
8	Canadiens	9	12/10/2016	MTL	vs	COL	W 10-1	10	1	1	2	0	3	36	16
9	Bruins	9	1/5/2012	BOS	vs	CGY	W 9-0	9	0	1	2	0	2	42	25
10	Hurricanes	9	4/7/2009	CAR	vs	NYI	W 9-0	9	0	4	11	0	1	57	12
11	Sabres	9	1/18/2008	BUF	vs	ATL	W 10-1	10	1	3	9	0	6	49	24
12	Sabres	9	1/14/2006	BUF	vs	LAK	W 10-1	10	1	3	9	0	7	34	33
13	Thrashers	9	11/12/2005	ATL	@	CAR	W 9-0	9	0	4	13	0	8	36	19
14	Lightning	9	11/8/2003	TBL	vs	PIT	W 9-0	9	0	1	8	0	4	42	15
15	Devils	9	10/28/2000	NJD	@	PIT	W 9-0	9	0	1	3	0	0	42	21
16	Lightning	8	3/27/2025	TBL	vs	UTA	W 8-0	8	0	1	2	0	2	22	25
17	Penguins	8	11/4/2023	PIT	@	SJS	W 10-2	10	2	2	4	2	6	35	26
18	Canadiens	8	4/29/2022	MTL	vs	FLA	W 10-2	10	2	1	2	1	1	37	39
19	Flames	8	4/16/2022	CGY	vs	ARI	W 9-1	9	1	0	2	0	2	41	26
20	Predators	8	3/5/2022	NSH	@	SJS	W 8-0	8	0	1	4	0	3	36	20
21	Blues	8	4/9/2021	STL	vs	MIN	W 9-1	9	1	1	2	0	2	38	25
22	Avalanche	8	1/15/2021	COL	vs	STL	W 8-0	8	0	5	7	0	4	38	21
23	Penguins	8	10/25/2018	PIT	@	CGY	W 9-1	9	1	2	2	0	3	36	39
24	Ducks	8	1/15/2014	ANA	vs	VAN	W 9-1	9	1	6	11	1	3	44	32
25	Bruins	8	3/19/2012	BOS	vs	TOR	W 8-0	8	0	2	2	0	2	24	13