The Florida Panthers had the highest goal differential by a team in 2021-22, with a differential of 95 goals.

	TEAM	DIFF	SEASON	GP	W	L	OTL	PTS	PTS%	SOW	SOL	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Panthers	95	2021-22	82	58	18	6	122	.744	3	4	337	242	24.4	79.5	37.34	11.0	30.67	.904
2	Flames	85	2021-22	82	50	21	11	111	.677	2	2	291	206	22.9	83.2	35.46	10.0	28.95	.913
3	Hurricanes	77	2021-22	82	54	20	8	116	.707	1	2	277	200	22.0	88.0	34.12	9.9	28.17	.913
4	Avalanche	76	2021-22	82	56	19	7	119	.726	4	2	308	232	24.0	79.7	35.05	10.7	32.01	.912
5	Blues	70	2021-22	82	49	22	11	109	.665	2	3	309	239	27.0	84.1	30.39	12.4	31.60	.908
6	Maple Leafs	60	2021-22	82	54	21	7	115	.701	3	1	312	252	27.3	82.1	34.57	11.0	30.62	.900
7	Lightning	57	2021-22	82	51	23	8	110	.671	2	5	285	228	23.9	80.6	30.91	11.2	29.77	.907
8	Wild	56	2021-22	82	53	22	7	113	.689	5	4	305	249	20.5	76.1	32.51	11.4	31.43	.903
9	Penguins	47	2021-22	82	46	25	11	103	.628	3	7	269	222	20.2	84.4	34.74	9.4	31.41	.914
10	Rangers	46	2021-22	82	52	24	6	110	.671	4	3	250	204	25.2	82.3	29.17	10.5	30.83	.919
11	Bruins	35	2021-22	82	51	26	5	107	.652	2	2	253	218	21.2	81.3	36.12	8.5	28.71	.907
12	Oilers	34	2021-22	82	49	27	6	104	.634	5	1	285	251	26.0	79.4	34.02	10.2	32.28	.905
13	Capitals	28	2021-22	82	44	26	12	100	.610	5	3	270	242	18.8	80.4	31.43	10.5	29.00	.898
14	Golden Knights	18	2021-22	82	43	31	8	94	.573	4	4	262	244	18.4	77.4	34.51	9.3	29.98	.901
15	Canucks	15	2021-22	82	40	30	12	92	.561	3	5	246	231	23.5	74.9	31.98	9.4	31.85	.912
16	Predators	12	2021-22	82	45	30	7	97	.591	4	2	262	250	24.4	79.2	29.74	10.7	32.27	.906
17	Kings	3	2021-22	82	44	27	11	99	.604	4	4	235	232	16.1	76.7	34.94	8.2	28.55	.901
18	Islanders	-2	2021-22	82	37	35	10	84	.512	2	6	229	231	22.1	84.2	28.87	9.7	32.55	.913
19	Jets	-3	2021-22	82	39	32	11	89	.543	2	4	250	253	21.1	75.0	32.26	9.5	33.18	.907
20	Stars	-11	2021-22	82	46	30	6	98	.598	5	2	233	244	22.4	79.0	30.32	9.4	31.04	.904
21	Ducks	-38	2021-22	82	31	37	14	76	.463	4	5	228	266	21.9	80.8	29.18	9.5	33.23	.902
22	Blue Jackets	-39	2021-22	82	37	38	7	81	.494	4	3	258	297	18.6	78.6	30.04	10.5	35.21	.897
23	Senators	-40	2021-22	82	33	42	7	73	.445	3	2	224	264	19.3	80.3	30.04	9.1	33.41	.904
24	Sharks	-50	2021-22	82	32	37	13	77	.470	3	3	211	261	19.0	85.2	29.27	8.8	31.98	.900
25	Devils	-57	2021-22	82	27	46	9	63	.384	3	5	245	302	15.6	80.2	31.24	9.6	30.98	.881