Between the 1959-60 and 1968-69 seasons, the Chicago Black Hawks had the highest goal differential by a team in a game, with a differential of 12 goals against the Flyers on January 30, 1969.

NHL team highest goal diff in a regular-season game 1960s

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	OPP PPG	S	SA
1	Black Hawks	12	1/30/1969	CHI	@	PHI	W 12-0	12	0	1	0	49	37
2	Bruins	11	1/18/1964	BOS	@	TOR	W 11-0	11	0	0	0	38	26
3	Bruins	9	2/27/1969	BOS	@	OAK	W 9-0	9	0	2	0	33	23
4	Rangers	9	2/23/1969	NYR	vs	BOS	W 9-0	9	0	2	0	44	21
5	Canadiens	9	3/15/1967	MTL	vs	BOS	W 11-2	11	2	3	0	43	25
6	Black Hawks	9	12/4/1965	CHI	@	BOS	W 10-1	10	1	3	0	31	41
7	Black Hawks	9	11/7/1965	CHI	vs	TOR	W 9-0	9	0	3	0	40	40
8	Maple Leafs	9	3/21/1965	TOR	@	NYR	W 10-1	10	1	3	0	43	29
9	Canadiens	9	1/21/1960	MTL	vs	NYR	W 11-2	11	2	1	0	45	30
10	Bruins	8	3/16/1969	BOS	vs	TOR	W 11-3	11	3	2	3	51	30
11	Red Wings	8	2/23/1969	DET	vs	PHI	W 9-1	9	1	1	1	49	29
12	Blues	8	11/7/1968	STL	@	PHI	W 8-0	8	0	0	0	30	26
13	Bruins	8	3/21/1968	BOS	vs	CHI	W 8-0	8	0	0	0	34	21
14	Flyers	8	12/31/1967	PHI	vs	LAK	W 9-1	9	1	3	0	32	38
15	Black Hawks	8	4/2/1967	CHI	@	NYR	W 8-0	8	0	0	0	33	33
16	Black Hawks	8	12/8/1966	CHI	@	BOS	W 10-2	10	2	1	0	44	31
17	Red Wings	8	12/2/1965	DET	vs	BOS	W 10-2	10	2	0	1	35	18
18	Maple Leafs	8	12/5/1964	TOR	vs	DET	W 10-2	10	2	3	0	41	36
19	Canadiens	8	3/7/1963	MTL	vs	BOS	W 8-0	8	0	2	0	44	26
20	Black Hawks	8	2/25/1962	CHI	vs	BOS	W 8-0	8	0	1	0	44	27
21	Canadiens	8	2/15/1962	MTL	vs	BOS	W 9-1	9	1	1	0	51	33
22	Maple Leafs	8	10/22/1961	TOR	@	BOS	W 9-1	9	1	1	1	37	40
23	Canadiens	8	2/16/1961	MTL	vs	BOS	W 9-1	9	1	2	0	36	27
24	Blues	7	11/20/1968	STL	vs	OAK	W 7-0	7	0	0	0	31	21
25	Rangers	7	10/20/1968	NYR	vs	LAK	W 7-0	7	0	1	0	45	26