Between the 1969-70 and 1978-79 seasons, the Toronto Maple Leafs had the highest goal differential by a team in a game, with a differential of 13 goals against the Red Wings on January 2, 1971.

NHL team highest goal diff in a regular-season game 1970s

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
1	Maple Leafs	13	1/2/1971	TOR	vs	DET	W 13-0	13	0	4		0		49	31
2	Canadiens	12	2/22/1979	MTL	vs	PIT	W 12-0	12	0	1	2	0	2	37	25
3	Sabres	12	12/21/1975	BUF	vs	WSH	W 14-2	14	2	1		1		50	16
4	Flyers	11	10/20/1977	PHI	vs	PIT	W 11-0	11	0	1	3	0	2	54	20
5	Canadiens	11	4/2/1977	MTL	vs	WSH	W 11-0	11	0	0		0		42	24
6	Penguins	11	3/15/1975	PIT	vs	WSH	W 12-1	12	1	0		0		65	24
7	Bruins	11	12/14/1974	BOS	vs	WSH	W 12-1	12	1	2		1		48	16
8	Maple Leafs	11	11/25/1972	TOR	vs	CGS	W 11-0	11	0	3		0		43	37
9	Rangers	11	11/21/1971	NYR	vs	CGS	W 12-1	12	1	1		0		52	16
10	Canadiens	10	3/8/1979	MTL	vs	VAN	W 11-1	11	1	0	2	0	1	46	26
11	Sabres	10	2/25/1978	BUF	@	CLE	W 13-3	13	3	4	5	0	1	50	26
12	Flyers	10	12/11/1977	PHI	vs	CLE	W 11-1	11	1	0	3	1	2	52	18
13	Maple Leafs	10	2/12/1977	TOR	vs	WSH	W 10-0	10	0	3		0		37	30
14	Flyers	10	11/2/1975	PHI	vs	KCS	W 10-0	10	0	2		0		51	19
15	Canadiens	10	1/4/1975	MTL	vs	WSH	W 10-0	10	0	5		0		47	17
16	Flyers	10	12/1/1974	PHI	vs	KCS	W 10-0	10	0	1		0		47	22
17	Rangers	10	11/17/1974	NYR	vs	CGS	W 10-0	10	0	1		0		40	14
18	Canadiens	10	11/10/1974	MTL	@	WSH	W 11-1	11	1	2		0		42	17
19	Kings	10	4/6/1974	LAK	vs	VAN	W 11-1	11	1	2		0		43	26
20	Flyers	10	2/2/1974	PHI	vs	DET	W 12-2	12	2	0		1		55	35
21	Flyers	10	3/4/1973	PHI	vs	TOR	W 10-0	10	0	2		0		41	29
22	Islanders	9	1/2/1979	NYI	vs	VAN	W 9-0	9	0	3	4	0	3	35	23
23	Red Wings	9	11/16/1977	DET	vs	STL	W 10-1	10	1	2	2	0	3	39	26
24	Islanders	9	11/1/1977	NYI	vs	AFM	W 9-0	9	0	0	2	0	4	37	21
25	Canadiens	9	10/7/1976	MTL	vs	PIT	W 10-1	10	1	2		1		43	27