Plenette Pierson has the highest plus/minus in a game, at +53 versus the Fever on August 18, 2017.

Interpreted as:

highest single regular-season game plus minus by a player

	NAME	+/-	DATE	TM		OPP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Plenette Pierson P. Pierson	+53	8/18/2017	MIN	vs	IND	22	10	6	4	1	0	4	7	57.1	1	1	100.0	1	1	100.0	67.2	1	5	0	1
2	Sylvia Fowles S. Fowles	+49	8/18/2017	MIN	vs	IND	24	25	6	0	0	1	9	12	75.0	0	0		7	9	77.8	78.3	4	2	1	1
3	Maya Moore M. Moore	+47	8/18/2017	MIN	vs	IND	24	11	4	4	2	0	3	8	37.5	0	1	0.0	5	5	100.0	53.9	1	3	1	2
4	Jessica Shepard J. Shepard	+46	8/2/2025	MIN	@	LVA	27	18	14	2	0	0	7	8	87.5	0	0		4	7	57.1	81.2	2	12	1	1
5	Tyasha Harris T. Harris	+45	8/14/2022	DAL	@	LAS	21	18	2	11	0	0	6	7	85.7	2	3	66.7	4	5	80.0	97.8	0	2	0	1
6	Natasha Cloud N. Cloud	+44	6/1/2025	NYL	vs	CON	21	8	2	7	1	0	3	3	100.0	2	2	100.0	0	0		133.3	0	2	1	1
7	Breanna Stewart B. Stewart	+44	6/1/2025	NYL	vs	CON	23	13	3	5	1	1	4	5	80.0	1	2	50.0	4	4	100.0	96.2	0	3	1	1
8	Candice Dupree C. Dupree	+44	7/10/2011	PHX	vs	TUL	24	12	5	3	0	1	5	7	71.4	0	0		2	2	100.0	76.1	2	3	1	0
9	Leonie Fiebich L. Fiebich	+43	6/1/2025	NYL	vs	CON	20	13	2	1	0	0	4	5	80.0	3	4	75.0	2	2	100.0	110.5	0	2	0	2
10	Betnijah Laney-Hamilton B. Laney-Hamilton	+43	5/16/2024	NYL	@	IND	30	12	2	1	0	0	3	10	30.0	0	4	0.0	6	6	100.0	47.5	0	2	1	2
11	Katie Douglas K. Douglas	+43	6/1/2006	CON	@	CHA	27	13	2	5	3	0	4	8	50.0	2	4	50.0	3	3	100.0	69.7	1	1	4	1
12	Cappie Pondexter C. Pondexter	+42	8/8/2006	PHX	vs	MIN	30	23	5	6	1	0	10	17	58.8	3	4	75.0	0	0		67.6	0	5	3	0
13	Erika de Souza E. de Souza	+41	8/16/2013	ATL	vs	CON	31	18	15	3	3	5	7	11	63.6	0	0		4	5	80.0	68.2	1	14	1	3
14	Courtney Williams C. Williams	+40	8/2/2025	MIN	@	LVA	24	9	6	9	2	1	4	5	80.0	1	1	100.0	0	0		90.0	0	6	0	1
15	Veronica Burton V. Burton	+40	6/7/2025	GSV	vs	LVA	32	14	7	12	0	1	4	10	40.0	0	2	0.0	6	6	100.0	55.4	1	6	0	4
16	Jonquel Jones J. Jones	+40	6/1/2025	NYL	vs	CON	23	13	11	0	0	0	4	7	57.1	3	4	75.0	2	2	100.0	82.5	1	10	3	4
17	Arike Ogunbowale A. Ogunbowale	+40	7/12/2023	DAL	@	MIN	36	18	5	11	3	0	6	16	37.5	2	9	22.2	4	4	100.0	50.7	0	5	1	1
18	Satou Sabally S. Sabally	+40	7/12/2023	DAL	@	MIN	33	19	8	5	2	0	7	14	50.0	5	8	62.5	0	0		67.9	3	5	2	2
19	Courtney Vandersloot C. Vandersloot	+40	6/14/2015	CHI	@	IND	26	14	0	4	3	2	6	10	60.0	2	3	66.7	0	0		70.0	0	0	3	2
20	Angel McCoughtry A. McCoughtry	+40	7/30/2010	ATL	@	CON	23	20	6	3	2	0	8	20	40.0	3	9	33.3	1	2	50.0	47.9	0	6	0	1
21	Asjha Jones A. Jones	+40	8/29/2008	CON	@	ATL	22	24	4	4	1	0	8	15	53.3	0	0		8	9	88.9	63.3	1	3	2	2
22	Rebekkah Brunson R. Brunson	+40	7/24/2005	SAC	vs	DET	31	11	14	1	1	0	3	9	33.3	0	0		5	10	50.0	41.0	7	7	1	2
23	NaLyssa Smith N. Smith	+39	9/11/2025	LVA	@	LAS	24	10	2	2	1	0	5	8	62.5	0	1	0.0	0	0		62.5	1	1	0	1
24	Tina Charles T. Charles	+39	7/27/2025	CON	vs	GSV	19	24	6	2	2	1	8	11	72.7	1	1	100.0	7	7	100.0	85.2	1	5	1	0
25	Ezi Magbegor E. Magbegor	+39	7/24/2025	SEA	@	CHI	23	9	5	1	1	3	3	6	50.0	0	1	0.0	3	5	60.0	54.9	1	4	0	1