Sergio Ramos has made the most career appearances by a defender in LaLiga, with 536 appearances.

	NAME	M	START	MIN	G	A	YC	RC
1	Sergio Ramos S. Ramos	536	530	46,782	77	6	193	21
2	Manuel Sanchis M. Sanchis	523	489	43,470	33		90	5
3	Miquel Soler M. Soler	504	418	38,848	11		27	0
4	Fernando Hierro F. Hierro	497	490	43,185	105		153	14
5	Lorenzo Juarros L. Juarros	481	447	39,550	53		111	11
6	Miquel Àngel Nadal M. Àngel Nadal	463	413	37,902	34		66	8
7	Alberto Górriz A. Górriz	461	440	39,881	14		50	1
8	Jon Andoni Larrañaga J. Andoni Larrañaga	460	427	38,958	15		39	1
9	Manuel Enrique Jiménez M. Enrique Jiménez	458	455	40,920	8		34	1
10	Cristóbal Parralo C. Parralo	454	443	39,713	14		77	3
11	Diego Rodríguez D. Rodríguez	450	445	39,403	11		59	8
12	Miguel Ángel Fuentes M. Ángel Fuentes	439	367	34,349	7		73	7
13	Dani Alves D. Alves	436	397	35,806	26	15	131	10
14	Francisco Fernández F. Fernández	433	417	37,490	26		26	2
15	Francisco Salinas F. Salinas	432	398	36,151	11		94	15
16	Juanfran	427	374	32,864	15	15	75	2
17	Gerard Piqué G. Piqué	421	398	35,304	31	4	120	9
18	Fernando Navarro F. Navarro	421	391	35,067	3	2	125	6
19	Pablo Alfaro P. Alfaro	418	399	35,614	7		100	18
20	José Antonio Camacho J. Antonio Camacho	414	407	36,369	9		33	1
21	Lopo	410	394	35,425	19	0	163	14
22	Capdevila	410	375	34,014	36	0	77	3
23	Iraola	406	376	33,595	33	5	60	1
24	Íñigo Martínez Í. Martínez	405	397	35,579	23	8	109	6
25	Enrique Fernández Romero E. Fernández Romero	396	373	33,159	14		48	3