Since 2000-01, James Milner has made the most appearances in the Premier League, with 645 appearances.

most games by a player after 2000

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	James Milner J. Milner	645	40,290	434	56	0.09	88	144	18
2	Gareth Barry G. Barry	589	49,162	560	50	0.08	62	112	18
3	Jermain Defoe J. Defoe	496	32,631	347	162	0.33	33	195	14
4	Wayne Rooney W. Rooney	491	38,027	421	208	0.42	100	308	23
5	Frank Lampard F. Lampard	491	39,557	444	160	0.33	93	253	42
6	John Terry J. Terry	486	41,660	471	41	0.08	12	53	0
7	Ashley Young A. Young	485	36,894	411	50	0.10	74	124	5
8	Michael Carrick M. Carrick	473	37,577	417	23	0.05	38	61	0
9	Sylvain Distin S. Distin	469	40,618	451	7	0.01	6	13	0
10	Peter Crouch P. Crouch	468	28,485	310	107	0.23	58	165	1
11	Steven Gerrard S. Gerrard	463	38,578	436	120	0.26	86	206	31
12	Jordan Henderson J. Henderson	446	33,352	374	33	0.07	54	87	1
13	John O'Shea J. O'Shea	445	33,068	370	13	0.03	13	26	0
14	Petr Čech P. Čech	443	39,495	442	0	0.00	2	2	0
15	Jussi Jääskeläinen J. Jääskeläinen	436	39,080	435	0	0.00	3	3	0
16	Mark Schwarzer M. Schwarzer	436	39,179	436	0	0.00	1	1	0
17	Kyle Walker K. Walker	425	35,864	403	8	0.02	37	45	0
18	Brad Friedel B. Friedel	425	38,178	425	1	0.00	0	1	0
19	Leighton Baines L. Baines	420	35,421	397	32	0.08	53	85	20
20	Aaron Lennon A. Lennon	416	27,990	312	36	0.09	50	86	0
21	Jamie Carragher J. Carragher	416	35,661	399	1	0.00	12	13	0
22	David De Gea D. De Gea	415	37,289	415	0	0.00	0	0	0
23	Mark Noble M. Noble	414	32,029	373	47	0.11	36	83	28
24	Aaron Hughes A. Hughes	410	35,374	396	3	0.01	11	14	0
25	James Ward-Prowse J. Ward-Prowse	409	28,920	319	57	0.14	45	102	15