Javier Zanetti has made the most career appearances by a player 22 or older in Europe's top five leagues, with 615 appearances in Serie A.

most games after turning 22 years old by a player

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	Javier Zanetti J. Zanetti	615	53,018	589	12	0.02	6	18	0
2	Joaquín	600	39,124	433	68	0.11	33	101	4
3	Miroslav Votava M. Votava	588	51,869	582	47	0.08			0
4	Gianluca Pagliuca G. Pagliuca	581	52,160	581	0	0.00			0
5	David James D. James	572	51,298	571	0	0.00	2	2	0
6	Steve Mandanda S. Mandanda	564	50,183	563	0	0.00	1	1	0
7	Pepe Reina P. Reina	563	50,396	561	0	0.00	6	6	0
8	Samir Handanovič S. Handanovič	559	49,980	559	0	0.00	0	0	0
9	Gianluigi Buffon G. Buffon	556	49,580	556	0	0.00	0	0	0
10	Fabio Quagliarella F. Quagliarella	551	37,901	432	182	0.33	34	216	32
11	Dino Zoff D. Zoff	551	49,564	551	0	0.00			0
12	Sylvain Pierre Kastendeuch S. Pierre Kastendeuch	550	48,835	550	28	0.05			21
13	Andoni Zubizarreta A. Zubizarreta	548	49,202	548	0	0.00			0
14	Francisco Buyo F. Buyo	542	48,719	542	0	0.00			0
15	Jesús Navas J. Navas	538	39,870	441	24	0.04	46	70	0
16	Pietro Vierchowod P. Vierchowod	538	47,371	533	37	0.07			0
17	Gary Speed G. Speed	535	46,319	521	80	0.15	44	124	10
18	Luka Modrić L. Modrić	534	39,157	446	44	0.08	77	121	3
19	Oliver Kahn O. Kahn	532	47,250	532	0	0.00			0
20	Jens Lehmann J. Lehmann	531	47,534	530	2	0.00			1
21	Mark Schwarzer M. Schwarzer	520	46,721	520	0	0.00	1	1	0
22	Claude Makélélé C. Makélélé	518	43,518	499	14	0.03	7	21	0
23	Michael Lameck M. Lameck	518	46,210	514	38	0.07			13
24	Enrico Albertosi E. Albertosi	514	45,780	513	0	0.00			0
25	Florent Balmont F. Balmont	513	39,332	460	13	0.03	28	41	1