Rui Costa has made the most career appearances by a Portuguese player in Serie A, with 339 appearances.

	NAME	M	RTG	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Rui Costa R. Costa	339		25,978	301	42	0.12			5
2	Mário Rui M. Rui	248		19,288	216	3	0.01	27	30	0	1	183	39	7	19,511	152	17
3	Fernando Manuel Couto F. Manuel Couto	247		19,457	217	14	0.06			0
4	Miguel Veloso M. Veloso	214		14,785	175	8	0.04	19	27	2
5	Rafael Leão R. Leão	205		13,683	152	59	0.29	43	102	2	0	428	165	13	7,183	960	53
6	Pedro Pereira P. Pereira	146		9,253	104	1	0.01	10	11	0	0	37	13	1	5,554	97	7
7	Sergio Conceição S. Conceição	137		9,457	107	13	0.09			0
8	Bruno Alves B. Alves	121		10,463	118	6	0.05	1	7	0	3	82	18	1	6,475	122	5
9	Bruno Fernandes B. Fernandes	119		6,994	79	15	0.13	11	26	1
10	Luís Figo L. Figo	105		6,394	68	9	0.09			2
11	Rui Patrício R. Patrício	99	6.77	8,910	99	0	0.00	0	0	0	0	0	0	0	3,040	1	0
12	Cristiano Ronaldo C. Ronaldo	98		8,441	94	81	0.83	15	96	23	1	554	218	17	5,059	647	92
13	Dany Mota D. Mota	94	6.49	6,091	69	14	0.15	6	20	0	0	109	34	3	2,901	276	26
14	Paulo Sousa P. Sousa	93		6,996	86	1	0.01			0
15	João Mário J. Mário	64		3,633	39	4	0.06	10	14	0	0	60	16	0	3,105	94	3
16	Rui de Barros R. de Barros	60		5,100	58	14	0.23			0
17	Nuno Ribeiro N. Ribeiro	53		4,184	50	14	0.26			0
18	João Cancelo J. Cancelo	51		3,812	42	2	0.04	6	8	0	1	36	8	2	3,753	66	4
19	José Mamede J. Mamede	50		3,520	38	1	0.02			0
20	Vitinha	45	6.53	2,155	25	5	0.11	3	8	0	0	62	16	0	1,056	100	13
21	Gonçalo Brandão G. Brandão	43		3,652	41	0	0.00	0	0	0
22	Tiago Mendes T. Mendes	42		2,332	26	0	0.00			0
23	Adrien Silva A. Silva	41		2,687	30	1	0.02	2	3	0	0	14	3	0	1,987	12	0
24	Eduardo	37		3,330	37	0	0.00	0	0	0
25	Pedro Mendes P. Mendes	36		2,591	28	0	0.00	0	0	0