Mohamed Salah has tallied the most career goals by an active player in the Premier League against Big Six opponents, with 50 goals.

most goals by a player against big six premier league all-time current players

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Mohamed Salah M. Salah	50	81	6,712	76	0.62	22	72	11
2	Jamie Vardy J. Vardy	45	108	8,408	95	0.42	10	55	8	0	188	92	8	2,258	328	88
3	Harry Kane H. Kane	39	81	7,007	78	0.48	9	48	11
4	Marcus Rashford M. Rashford	27	82	5,719	64	0.33	9	36	4	0	130	65	6	2,436	274	39
5	Kevin De Bruyne K. De Bruyne	23	77	5,896	67	0.30	19	42	2
6	Erling Haaland E. Haaland	22	30	2,609	29	0.73	8	30	3	0	102	52	2	715	179	3
7	Danny Welbeck D. Welbeck	20	109	6,526	73	0.18	8	28	0
8	Ollie Watkins O. Watkins	19	59	5,009	57	0.32	7	26	0	0	122	52	3	1,671	269	38
9	Leandro Trossard L. Trossard	18	62	3,850	44	0.29	5	23	0	0	101	37	3	2,046	221	18
10	Olivier Giroud O. Giroud	17	68	3,466	36	0.25	3	20	0
11	Romelu Lukaku R. Lukaku	17	86	6,366	69	0.20	6	23	1
12	Andy Carroll A. Carroll	17	77	4,239	44	0.22	4	21	1
13	James Maddison J. Maddison	16	70	5,281	62	0.23	11	27	0	1	139	52	4	3,507	170	12
14	Alexander Isak A. Isak	15	27	2,161	26	0.56	2	17	0	0	64	27	3	748	131	16
15	Phil Foden P. Foden	15	54	3,487	39	0.28	5	20	0	0	98	42	3	2,302	207	12
16	Jarrod Bowen J. Bowen	15	67	5,311	61	0.22	9	24	1	0	115	44	5	2,115	235	24
17	James Ward-Prowse J. Ward-Prowse	15	134	9,653	104	0.11	14	29	3
18	Bruno Fernandes B. Fernandes	14	53	4,593	53	0.26	8	22	6	1	110	38	4	3,302	124	16
19	Bukayo Saka B. Saka	14	52	4,057	47	0.27	9	23	5	0	91	34	2	2,306	233	19
20	Ilkay Gündogan I. Gündogan	14	60	3,997	43	0.23	4	18	1	0	78	27	5	3,509	115	3
21	Callum Wilson C. Wilson	14	72	4,444	49	0.19	4	18	4	0	92	31	1	1,397	221	43
22	Danny Ings D. Ings	14	66	3,904	45	0.21	2	16	2	0	117	45	1	1,551	164	18
23	Richarlison	13	73	5,383	60	0.18	6	19	0	0	153	57	2	2,519	304	49
24	Ashley Barnes A. Barnes	13	63	4,071	44	0.21	0	13	1	0	109	40	1	1,664	130	53
25	Edin Džeko E. Džeko	13	34	1,741	19	0.38	2	15	0