Between the 1999-00 and 2009-10 seasons, Francesco Totti scored the most goals in Serie A, with 156 goals.

	NAME	G	M	MIN	START	G/M	PK
1	Francesco Totti F. Totti	156	295	25,066	289	0.53	45
2	Alberto Gilardino A. Gilardino	128	317	21,914	239	0.40	10
3	Andriy Shevchenko A. Shevchenko	127	226	17,174	195	0.56	24
4	Alessandro Del Piero A. Del Piero	127	291	21,065	246	0.44	38
5	David Trezeguet D. Trezeguet	123	214	15,665	180	0.57	6
6	Christian Vieri C. Vieri	114	193	13,002	135	0.59	15
7	Cristiano Lucarelli C. Lucarelli	114	264	21,359	246	0.43	23
8	Hernán Crespo H. Crespo	104	225	15,464	177	0.46	9
9	Antonio Di Natale A. Di Natale	102	252	19,278	220	0.40	14
10	Marco Di Vaio M. Di Vaio	98	228	15,544	170	0.43	10
11	Luca Toni L. Toni	96	192	15,930	181	0.50	6
12	Filippo Inzaghi F. Inzaghi	96	250	16,284	177	0.38	3
13	Tommaso Rocchi T. Rocchi	91	270	20,862	236	0.34	7
14	Adrian Mutu A. Mutu	91	223	16,640	195	0.41	17
15	Vincenzo Montella V. Montella	87	205	12,709	140	0.42	8
16	Nicola Amoruso N. Amoruso	87	286	20,336	220	0.30	18
17	Vincenzo Iaquinta V. Iaquinta	84	243	15,440	168	0.35	13
18	Zlatan Ibrahimovic Z. Ibrahimovic	80	158	12,418	142	0.51	11
19	Julio Cruz J. Cruz	80	243	15,355	169	0.33	9
20	Adriano	77	175	12,702	141	0.44	7
21	Antonio Cassano A. Cassano	76	255	18,213	202	0.30	5
22	Cristiano Doni C. Doni	75	244	19,378	221	0.31	19
23	Kaká	70	193	15,493	174	0.36	19
24	Fabrizio Miccoli F. Miccoli	70	181	13,229	158	0.39	13
25	Enrico Chiesa E. Chiesa	68	200	13,705	161	0.34	10