Luis Muriel has the most career goals by a player off the bench in Serie A, with 27 goals.

most goals by a player off the bench all-time

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Luis Muriel L. Muriel	27	143	3,383	0	0.19	8	35	2
2	Alessandro Matri A. Matri	25	147	3,151	0	0.17	4	29	1
3	Giampaolo Pazzini G. Pazzini	22	152	3,661	0	0.14	2	24	8
4	Lautaro Martínez L. Martínez	19	49	1,067	0	0.39	4	23	2	0	85	40	1	626	119	5
5	Alessandro Del Piero A. Del Piero	19	100	2,178	0	0.19	1	20	2
6	Mirko Vučinić M. Vučinić	18	81	1,735	0	0.22	2	20	2
7	Julio Cruz J. Cruz	18	74	1,664	0	0.24			2
8	Vincenzo Iaquinta V. Iaquinta	18	87	1,855	0	0.21	0	18	4
9	Vincenzo Montella V. Montella	18	68	1,785	0	0.26			2
10	Nicola Amoruso N. Amoruso	17	100	2,779	0	0.17			3
11	Marco Di Vaio M. Di Vaio	16	72	1,861	0	0.22	0	16	1
12	Pedro	15	94	2,377	0	0.16	2	17	2	0	74	30	3	1,827	124	6
13	Riccardo Orsolini R. Orsolini	15	87	1,957	0	0.17	6	21	4	0	93	31	2	1,391	132	10
14	Manolo Gabbiadini M. Gabbiadini	15	105	2,077	0	0.14	5	20	2
15	Sergio Pellissier S. Pellissier	15	154	3,444	0	0.10	3	18	1
16	Antonio Cassano A. Cassano	15	83	2,279	0	0.18	5	20	2
17	Alberto Gilardino A. Gilardino	15	108	2,552	0	0.14	2	17	0
18	Anselmo Robbiati A. Robbiati	15	90	2,158	0	0.17			0
19	Maurizio Ganz M. Ganz	15	81	1,757	0	0.19			2
20	Josip Iličić J. Iličić	14	88	2,376	0	0.16	14	28	1
21	Goran Pandev G. Pandev	14	172	4,092	0	0.08	8	22	1
22	Nicola Ventola N. Ventola	14	92	2,166	0	0.15			1
23	Matteo Politano M. Politano	13	98	2,041	0	0.13	4	17	2	0	94	28	4	1,679	132	1
24	Duván Zapata D. Zapata	13	79	1,768	0	0.16	5	18	1
25	Alberto Paloschi A. Paloschi	13	100	1,954	0	0.13	1	14	1