Jermain Defoe has the most career goals by a player off the bench in the Premier League, with 24 goals.

most goals by a player off the bench all-time

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Jermain Defoe J. Defoe	24	149	2,913	0	0.16	3	27	0
2	Olivier Giroud O. Giroud	21	103	1,910	0	0.20	2	23	0
3	Javier Hernández J. Hernández	19	78	1,678	0	0.24	1	20	0
4	Danny Welbeck D. Welbeck	18	140	2,856	0	0.13	4	22	0
5	Daniel Sturridge D. Sturridge	17	98	1,705	0	0.17	7	24	1
6	Nwankwo Kanu N. Kanu	17	118	2,591	0	0.14	12	29	0
7	Ole Gunnar Solskjær O. Gunnar Solskjær	17	84	1,493	0	0.20	5	22	0
8	Peter Crouch P. Crouch	16	158	2,705	0	0.10	6	22	0
9	Marcus Rashford M. Rashford	13	76	1,804	0	0.17	3	16	0	0	64	26	4	1,185	162	8
10	Edin Džeko E. Džeko	13	56	1,079	0	0.23	4	17	0
11	Victor Anichebe V. Anichebe	13	107	1,960	0	0.12	5	18	0
12	James Milner J. Milner	13	211	3,829	0	0.06	6	19	4
13	Darren Bent D. Bent	13	60	1,329	0	0.22	1	14	1
14	Robbie Keane R. Keane	13	76	1,547	0	0.17	4	17	0
15	Tore André Flo T. André Flo	13	59	1,395	0	0.22	3	16	0
16	Michael Owen M. Owen	13	69	1,397	0	0.19	0	13	0
17	Andy Cole A. Cole	13	64	1,492	0	0.20	5	18	0
18	Romelu Lukaku R. Lukaku	12	53	1,235	0	0.23	1	13	1
19	Sergio Agüero S. Agüero	12	40	990	0	0.30	3	15	1
20	Diogo Jota D. Jota	11	55	1,184	0	0.20	2	13	0	0	63	22	2	794	131	1
21	Anthony Martial A. Martial	11	60	1,210	0	0.18	3	14	2	0	33	17	0	867	114	11
22	Divock Origi D. Origi	11	87	1,312	0	0.13	3	14	0	0	45	21	2	713	81	10
23	Shane Long S. Long	11	158	2,816	0	0.07	6	17	1
24	Salomon Kalou S. Kalou	11	62	1,222	0	0.18	4	15	0
25	Didier Drogba D. Drogba	11	67	1,694	0	0.16	3	14	0