Silvio Piola has the most career goals by a player against a club in Serie A, with 22 goals versus Milan.

most goals by a player scored against a single team for a player in soccer all-time against big clubs

	NAME	G	OPP	M	MIN	START	G/M	A	G+A	PK
1	Silvio Piola S. Piola	22	Milan	34	3,060	34	0.65			3
2	Silvio Piola S. Piola	21	Fiorentina	32	2,880	32	0.66			1
3	Francesco Totti F. Totti	19	Parma	34	2,793	32	0.56	1	20	1
4	Nils Gunnar Nordahl N. Gunnar Nordahl	19	Triestina	17	1,530	17	1.12			0
5	Guglielmo Gabetto G. Gabetto	18	Bari	17	1,530	17	1.06			0
6	Roberto Mancini R. Mancini	17	Udinese	23	1,880	20	0.74			1
7	José João Altafini J. João Altafini	17	Torino	26	2,246	25	0.65			0
8	José João Altafini J. João Altafini	17	Juventus	24	2,160	24	0.71			1
9	Kurt Roland Hamrin K. Roland Hamrin	17	Genoa	11	990	11	1.55			4
10	Silvio Piola S. Piola	17	Triestina	35	3,150	35	0.49			2
11	Giuseppe Meazza G. Meazza	17	Lazio	21	1,845	21	0.81			1
12	Alessandro Altobelli A. Altobelli	16	Roma	23	1,935	22	0.70			4
13	Giuseppe Savoldi G. Savoldi	16	Roma	28	2,520	28	0.57			5
14	José João Altafini J. João Altafini	16	Vicenza	30	2,574	28	0.53			0
15	Kurt Roland Hamrin K. Roland Hamrin	16	Torino	22	1,980	22	0.73			1
16	Silvio Piola S. Piola	16	Liguria	14	1,260	14	1.14			1
17	Silvio Piola S. Piola	16	Napoli	29	2,610	29	0.55			0
18	Giuseppe Meazza G. Meazza	16	Torino	22	1,980	22	0.73			1
19	Ciro Immobile C. Immobile	15	Sampdoria	18	1,414	16	0.83	1	16	4
20	Alberto Gilardino A. Gilardino	15	Udinese	25	1,909	21	0.60	0	15	0
21	Francesco Totti F. Totti	15	Sampdoria	24	1,739	20	0.63	3	18	3
22	Luigi Riva L. Riva	15	Bologna	19	1,651	19	0.79			4
23	José João Altafini J. João Altafini	15	Bologna	32	2,667	29	0.47			0
24	José João Altafini J. João Altafini	15	Roma	30	2,589	28	0.50			2
25	José João Altafini J. João Altafini	15	Inter	30	2,565	28	0.50			1