Lionel Messi has the most career goals by a player against a club in LaLiga, with 30 goals against Sevilla.

most goals by a player scored against a single team for a player in soccer all-time against big clubs

	NAME	G	OPP	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Lionel Messi L. Messi	30	Sevilla	29	2,439	28	1.03	5	35	1
2	Lionel Messi L. Messi	27	Valencia	29	2,491	28	0.93	4	31	6
3	Lionel Messi L. Messi	26	Atlético Madrid	30	2,438	27	0.87	3	29	1
4	Cristiano Ronaldo C. Ronaldo	25	Sevilla	15	1,309	15	1.67	0	25	4
5	Telmo Zarra T. Zarra	24	Celta Vigo	20	1,800	20	1.20			0
6	Cristiano Ronaldo C. Ronaldo	23	Getafe	14	1,199	14	1.64	1	24	6
7	Lionel Messi L. Messi	23	Levante	21	1,719	19	1.10	11	34	5
8	Lionel Messi L. Messi	23	Osasuna	20	1,554	17	1.15	3	26	2
9	Guillermo Gorostiza G. Gorostiza	23	Barcelona	24	2,160	24	0.96			1
10	Lionel Messi L. Messi	22	Real Betis	22	1,604	17	1.00	8	30	4
11	Lionel Messi L. Messi	22	Espanyol	27	2,231	24	0.81	4	26	5
12	Lionel Messi L. Messi	20	Eibar	11	990	11	1.82	3	23	4	0	54	36	1	812	68	9
13	Lionel Messi L. Messi	20	Deportivo	17	1,408	15	1.18	4	24	0
14	Edmundo Suárez E. Suárez	20	Celta Vigo	17	1,530	17	1.18			0
15	Edmundo Suárez E. Suárez	20	Sevilla	19	1,710	19	1.05			0
16	Karim Benzema K. Benzema	18	Athletic Club	27	2,034	24	0.67	3	21	1
17	Lionel Messi L. Messi	18	Athletic Club	27	2,158	24	0.67	6	24	3
18	Lionel Messi L. Messi	18	Real Madrid	29	2,532	28	0.62	3	21	4
19	César Rodríguez C. Rodríguez	18	Oviedo	20	1,800	20	0.90			3
20	Telmo Zarra T. Zarra	18	Oviedo	21	1,890	21	0.86			0
21	Telmo Zarra T. Zarra	18	Español	21	1,890	21	0.86			1
22	Isidro Lángara I. Lángara	18	Español	8	720	8	2.25			2
23	Lionel Messi L. Messi	17	Rayo	10	884	10	1.70	4	21	2
24	Cristiano Ronaldo C. Ronaldo	17	Málaga	17	1,530	17	1.00	3	20	3
25	Cristiano Ronaldo C. Ronaldo	17	Athletic Club	18	1,520	17	0.94	5	22	4