Clint Dempsey has tallied the most career goals by an American in the Premier League, with 57 goals.

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Clint Dempsey C. Dempsey	57	218	16,698	183	0.26	19	76	2
2	Brian McBride B. McBride	36	148	9,751	109	0.24	9	45	0
3	Christian Pulisic C. Pulisic	20	98	5,563	58	0.20	9	29	0	0	153	59	2	3,448	380	12
4	Roy Wegerle R. Wegerle	13	75	5,268	57	0.17	6	19	2
5	Carlos Bocanegra C. Bocanegra	8	116	9,470	105	0.07	0	8	0
6	Joe-Max Moore J. Moore	8	52	2,416	22	0.15	2	10	0
7	Claudio Reyna C. Reyna	7	105	8,140	97	0.07	4	11	0
8	Preki	4	46	2,269	22	0.09	1	5	0
9	DaMarcus Beasley D. Beasley	3	18	1,028	11	0.17	1	4	0
10	Chris Richards C. Richards	2	66	5,088	56	0.03	1	3	0	0	30	9	0	2,990	53	3
11	Josh Sargent J. Sargent	2	26	1,579	18	0.08	1	3	0	0	23	3	0	687	58	4
12	DeAndre Yedlin D. Yedlin	2	109	8,512	95	0.02	5	7	0	0	24	4	0	5,084	45	16
13	Geoff Cameron G. Cameron	2	168	13,567	149	0.01	4	6	0
14	Tim Ream T. Ream	2	97	8,251	95	0.02	1	3	0
15	Jozy Altidore J. Altidore	2	70	3,543	37	0.03	4	6	0
16	Landon Donovan L. Donovan	2	17	1,280	14	0.12	6	8	0
17	Stuart Holden S. Holden	2	28	2,410	27	0.07	2	4	0
18	Jay DeMerit J. DeMerit	2	32	2,756	29	0.06	0	2	0
19	Jovan Kirovski J. Kirovski	2	23	591	5	0.09	0	2	0
20	Cobi Jones C. Jones	2	21	1,483	16	0.10	1	3	0
21	John Harkes J. Harkes	2	43	3,026	33	0.05	0	2	0
22	Brenden Aaronson B. Aaronson	1	43	2,782	32	0.02	3	4	0	0	49	12	4	1,484	95	6
23	Eric Lichaj E. Lichaj	1	32	2,231	21	0.03	2	3	0
24	Jonathan Spector J. Spector	1	124	8,142	81	0.01	1	2	0
25	Tim Howard T. Howard	1	399	35,752	398	0.00	3	4	0