Since 1999-00, James Milner has made the most appearances in the Premier League, with 645 appearances.

most playoff appearances by a player since 2000

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	James Milner J. Milner	645	40,285	434	56	0.09	88	144	18
2	Gareth Barry G. Barry	619	51,862	590	51	0.08	63	114	18
3	Frank Lampard F. Lampard	525	42,617	478	167	0.32	96	263	42
4	Jermain Defoe J. Defoe	496	32,631	347	162	0.33	33	195	14
5	Steven Gerrard S. Gerrard	492	40,728	462	121	0.25	89	210	31
6	Wayne Rooney W. Rooney	491	38,027	421	208	0.42	100	308	23
7	John Terry J. Terry	490	41,919	473	41	0.08	12	53	0
8	Ashley Young A. Young	485	36,894	411	50	0.10	74	124	5
9	Michael Carrick M. Carrick	481	38,052	421	24	0.05	40	64	0
10	Mark Schwarzer M. Schwarzer	473	42,509	473	0	0.00	1	1	0
11	Sylvain Distin S. Distin	469	40,618	451	7	0.01	6	13	0
12	Peter Crouch P. Crouch	468	28,485	310	107	0.23	58	165	1
13	Jamie Carragher J. Carragher	452	38,648	432	1	0.00	12	13	0
14	John O'Shea J. O'Shea	445	33,068	370	13	0.03	13	26	0
15	Petr Čech P. Čech	443	39,495	442	0	0.00	2	2	0
16	Jordan Henderson J. Henderson	440	32,882	369	33	0.08	53	86	1
17	Aaron Hughes A. Hughes	437	37,367	418	5	0.01	13	18	0
18	Jussi Jääskeläinen J. Jääskeläinen	436	39,080	435	0	0.00	3	3	0
19	Brad Friedel B. Friedel	427	38,358	427	1	0.00	0	1	0
20	Rio Ferdinand R. Ferdinand	422	37,004	415	9	0.02	7	16	0
21	Leighton Baines L. Baines	420	35,421	397	32	0.08	53	85	20
22	Kyle Walker K. Walker	419	35,324	397	8	0.02	37	45	0
23	Aaron Lennon A. Lennon	416	27,990	312	36	0.09	50	86	0
24	David De Gea D. De Gea	415	37,289	415	0	0.00	0	0	0
25	Emile Heskey E. Heskey	415	29,285	345	84	0.20	39	123	0