Ryan Giggs has the most career assists in the Premier League against Big Six opponents, with 41 assists.

most premier league assists by a player vs big six all-time

	NAME	A	M	MIN	START	G	G/M	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Ryan Giggs R. Giggs	41	170	12,423	138	18	0.11	59	2
2	Cesc Fàbregas C. Fàbregas	29	96	7,390	82	9	0.09	38	0
3	Steven Gerrard S. Gerrard	23	129	10,736	123	22	0.17	45	8
4	Mohamed Salah M. Salah	22	83	6,887	78	50	0.60	72	11
5	Ashley Young A. Young	21	148	11,132	124	9	0.06	30	3
6	Frank Lampard F. Lampard	21	158	12,798	144	26	0.16	47	10
7	Kevin De Bruyne K. De Bruyne	19	77	5,896	67	23	0.30	42	2
8	David Silva D. Silva	19	79	6,370	73	10	0.13	29	0
9	Alan Shearer A. Shearer	19	129	11,314	126	56	0.43	75	7
10	Didier Drogba D. Drogba	18	68	4,800	51	21	0.31	39	0
11	Kevin Davies K. Davies	18	138	10,884	124	22	0.16	40	1
12	Trent Alexander-Arnold T. Alexander-Arnold	17	70	5,533	63	4	0.06	21	0	1	80	21	4	5,354	96	4
13	Riyad Mahrez R. Mahrez	17	85	5,694	65	15	0.18	32	2	0	147	54	7	3,801	213	22
14	Christian Eriksen C. Eriksen	17	81	6,353	73	10	0.12	27	0
15	Dennis Bergkamp D. Bergkamp	17	75	5,202	59	12	0.16	29	0
16	Matt Le Tissier M. Le Tissier	16	78	5,572	62	21	0.27	37	3
17	Jordan Henderson J. Henderson	15	124	9,454	106	9	0.07	24	1
18	James Milner J. Milner	15	193	12,502	137	13	0.07	28	5
19	Stewart Downing S. Downing	15	132	10,369	114	10	0.08	25	2
20	Emile Heskey E. Heskey	15	144	10,601	124	21	0.15	36	0
21	Darren Anderton D. Anderton	15	70	5,259	59	6	0.09	21	0
22	James Ward-Prowse J. Ward-Prowse	14	134	9,653	104	15	0.11	29	3
23	Wayne Rooney W. Rooney	14	135	10,635	117	45	0.33	59	6
24	Gareth Barry G. Barry	14	197	16,704	188	12	0.06	26	4
25	Graeme Le Saux G. Le Saux	14	89	7,458	87	4	0.04	18	0