Cristiano Ronaldo scored 21 goals in the Premier League against Big Six opponents in his career.

	NAME	DATE	G	CLUB		OPP	MIN	A	PK	YC	RC
1	Cristiano Ronaldo C. Ronaldo	9/21/2003	0	Man United	vs	Arsenal	90	0	0	1	0
2	Cristiano Ronaldo C. Ronaldo	11/30/2003	0	Man United	@	Chelsea	18	0	0	0	0
3	Cristiano Ronaldo C. Ronaldo	12/13/2003	0	Man United	vs	Man City	17	0	0	0	0
4	Cristiano Ronaldo C. Ronaldo	12/21/2003	0	Man United	@	Tottenham	12	0	0	0	0
5	Cristiano Ronaldo C. Ronaldo	3/14/2004	0	Man United	@	Man City	72	0	0	0	0
6	Cristiano Ronaldo C. Ronaldo	3/20/2004	1	Man United	vs	Tottenham	16	0	0	0	0
7	Cristiano Ronaldo C. Ronaldo	4/24/2004	0	Man United	vs	Liverpool	90	0	0	1	0
8	Cristiano Ronaldo C. Ronaldo	5/8/2004	0	Man United	vs	Chelsea	87	0	0	0	0
9	Cristiano Ronaldo C. Ronaldo	9/20/2004	0	Man United	vs	Liverpool	90	0	0	0	0
10	Cristiano Ronaldo C. Ronaldo	9/25/2004	0	Man United	@	Tottenham	90	0	0	0	0
11	Cristiano Ronaldo C. Ronaldo	10/24/2004	0	Man United	vs	Arsenal	85	0	0	0	0
12	Cristiano Ronaldo C. Ronaldo	11/7/2004	0	Man United	vs	Man City	90	0	0	0	0
13	Cristiano Ronaldo C. Ronaldo	1/4/2005	0	Man United	vs	Tottenham	84	0	0	0	0
14	Cristiano Ronaldo C. Ronaldo	1/15/2005	0	Man United	@	Liverpool	66	1	0	0	0
15	Cristiano Ronaldo C. Ronaldo	2/1/2005	2	Man United	@	Arsenal	69	0	0	1	0
16	Cristiano Ronaldo C. Ronaldo	2/13/2005	0	Man United	@	Man City	58	0	0	0	0
17	Cristiano Ronaldo C. Ronaldo	5/10/2005	0	Man United	vs	Chelsea	90	0	0	0	0
18	Cristiano Ronaldo C. Ronaldo	9/18/2005	0	Man United	@	Liverpool	90	0	0	0	0
19	Cristiano Ronaldo C. Ronaldo	10/22/2005	0	Man United	vs	Tottenham	15	0	0	0	0
20	Cristiano Ronaldo C. Ronaldo	11/6/2005	0	Man United	vs	Chelsea	90	1	0	1	0
21	Cristiano Ronaldo C. Ronaldo	1/3/2006	0	Man United	@	Arsenal	90	0	0	0	0
22	Cristiano Ronaldo C. Ronaldo	1/14/2006	0	Man United	@	Man City	65	0	0	0	1
23	Cristiano Ronaldo C. Ronaldo	4/9/2006	0	Man United	vs	Arsenal	90	0	0	0	0
24	Cristiano Ronaldo C. Ronaldo	4/17/2006	0	Man United	@	Tottenham	89	1	0	0	0
25	Cristiano Ronaldo C. Ronaldo	4/29/2006	0	Man United	@	Chelsea	65	0	0	1	0
	Total		21				4,433	8	6	16	2