Between the 2009-10 and 2021-22 seasons, Lionel Messi had the most goals in Europe's top five leagues, with 426 goals in LaLiga and Ligue 1.

	NAME	G	M	MIN	START	G/M	A	G+A	PK
1	Lionel Messi L. Messi	426	437	36,811	404	0.97	120	546	53
2	Cristiano Ronaldo C. Ronaldo	410	420	36,030	405	0.98	62	472	87
3	Robert Lewandowski R. Lewandowski	312	384	31,081	347	0.81	56	368	40
4	Luis Suárez L. Suárez	247	368	29,863	336	0.67	96	343	14
5	Edinson Cavani E. Cavani	241	379	28,612	319	0.64	39	280	37
6	Zlatan Ibrahimovic Z. Ibrahimovic	221	305	24,113	274	0.72	70	291	46
7	Karim Benzema K. Benzema	219	415	29,998	351	0.53	77	296	18
8	Pierre-Emerick Aubameyang P. Aubameyang	218	409	31,822	356	0.53	54	272	20
9	Sergio Agüero S. Agüero	217	342	24,893	292	0.63	47	264	28
10	Gonzalo Higuaín G. Higuaín	205	350	25,364	287	0.59	29	234	12
11	Ciro Immobile C. Immobile	187	322	24,327	274	0.58	44	231	44
12	Harry Kane H. Kane	183	282	23,545	264	0.65	44	227	28
13	Edin Džeko E. Džeko	180	416	29,360	317	0.43	60	240	5
14	Romelu Lukaku R. Lukaku	168	350	26,541	290	0.48	46	214	19
15	Wissam Ben Yedder W. Ben Yedder	164	347	25,060	287	0.47	48	212	30
16	Antoine Griezmann A. Griezmann	159	421	32,466	380	0.38	46	205	7
17	Mohamed Salah M. Salah	155	274	21,583	245	0.57	66	221	18
18	Alexandre Lacazette A. Lacazette	154	361	25,276	288	0.43	44	198	28
19	Mauro Icardi M. Icardi	144	283	20,558	228	0.51	32	176	20
20	Marco Reus M. Reus	144	340	26,914	314	0.42	86	230	13
21	Kevin Gameiro K. Gameiro	143	402	23,712	256	0.36	34	177	15
22	Fabio Quagliarella F. Quagliarella	140	387	26,940	311	0.36	33	173	31
23	Neymar	137	215	17,855	200	0.64	72	209	29
24	Thomas Müller T. Müller	137	411	31,256	362	0.33	154	291	14
25	Antonio Di Natale A. Di Natale	136	228	17,651	202	0.60	27	163	25