The Cincinnati Reds had the highest run differential by a team in a game in 2025, with a differential of 22 runs versus the Orioles on April 20, 2025.
Interpreted as:
2025 MLB biggest margin of victory in a regular-season game| TEAM | DIFF | DATE | TM | OPP | RESULT | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Reds | 22 | 4/20/2025 | @ | W 24-2 | 51 | 24 | 25 | 4 | 1 | 3 | 23 | 11 | 2 | 6 | 1 | 0 | 64 | 40 | 8 | 0 | 0 | 0 | 1 | .490 | .594 | .784 | 1.378 | ||
| 2 |  | Padres | 21 | 5/10/2025 | @ | W 21-0 | 50 | 21 | 24 | 4 | 1 | 5 | 20 | 5 | 0 | 4 | 0 | 0 | 56 | 45 | 10 | 0 | 1 | 0 | 0 | .480 | .518 | .900 | 1.418 | ||
| 3 |  | Royals | 19 | 9/19/2025 | vs | W 20-1 | 51 | 20 | 27 | 7 | 0 | 3 | 20 | 5 | 0 | 6 | 1 | 0 | 56 | 43 | 10 | 0 | 0 | 0 | 0 | .529 | .571 | .843 | 1.415 | ||
| 4 |  | Blue Jays | 19 | 8/6/2025 | @ | W 20-1 | 49 | 20 | 24 | 7 | 1 | 5 | 20 | 4 | 2 | 6 | 0 | 0 | 57 | 48 | 13 | 0 | 2 | 0 | 0 | .490 | .526 | .980 | 1.506 | ||
| 5 |  | Orioles | 18 | 7/26/2025 | vs | W 18-0 | 40 | 18 | 18 | 4 | 0 | 3 | 16 | 6 | 1 | 4 | 1 | 0 | 47 | 31 | 7 | 0 | 0 | 0 | 3 | .450 | .532 | .775 | 1.307 | ||
| 6 |  | Rangers | 17 | 8/27/2025 | vs | W 20-3 | 46 | 20 | 22 | 5 | 0 | 4 | 20 | 4 | 2 | 6 | 0 | 0 | 53 | 39 | 9 | 0 | 1 | 0 | 0 | .478 | .528 | .848 | 1.376 | ||
| 7 |  | Astros | 17 | 7/4/2025 | @ | W 18-1 | 44 | 18 | 20 | 6 | 0 | 5 | 17 | 8 | 1 | 8 | 0 | 1 | 54 | 41 | 11 | 0 | 1 | 1 | 1 | .455 | .537 | .932 | 1.469 | ||
| 8 |  | Dodgers | 17 | 5/15/2025 | vs | W 19-2 | 40 | 19 | 18 | 2 | 0 | 5 | 19 | 8 | 0 | 6 | 2 | 0 | 50 | 35 | 7 | 0 | 2 | 0 | 0 | .450 | .520 | .875 | 1.395 | ||
| 9 |  | Mariners | 16 | 9/7/2025 | @ | W 18-2 | 45 | 18 | 19 | 1 | 1 | 5 | 14 | 3 | 2 | 7 | 2 | 0 | 51 | 37 | 7 | 0 | 1 | 0 | 1 | .422 | .471 | .822 | 1.293 | ||
| 10 | | Dodgers | 16 | 5/31/2025 | vs | W 18-2 | 43 | 18 | 21 | 5 | 0 | 5 | 18 | 7 | 0 | 5 | 0 | 0 | 51 | 41 | 10 | 0 | 1 | 0 | 1 | .488 | .549 | .953 | 1.503 | ||
| 11 |  | Cubs | 16 | 4/12/2025 | @ | W 16-0 | 47 | 16 | 21 | 5 | 0 | 4 | 16 | 4 | 1 | 4 | 1 | 0 | 53 | 38 | 9 | 0 | 1 | 0 | 0 | .447 | .491 | .809 | 1.299 | ||
| 12 |  | Phillies | 15 | 8/28/2025 | vs | W 19-4 | 44 | 19 | 20 | 3 | 1 | 7 | 19 | 4 | 0 | 3 | 0 | 0 | 48 | 46 | 11 | 0 | 0 | 0 | 0 | .455 | .500 | 1.045 | 1.545 | ||
| 13 |  | Rays | 15 | 4/14/2025 | vs | W 16-1 | 40 | 16 | 16 | 2 | 0 | 4 | 16 | 4 | 0 | 9 | 1 | 0 | 44 | 30 | 6 | 0 | 0 | 0 | 1 | .400 | .455 | .750 | 1.205 | ||
| 14 |  | Brewers | 15 | 4/9/2025 | @ | W 17-2 | 40 | 17 | 13 | 2 | 0 | 3 | 15 | 5 | 0 | 6 | 3 | 0 | 46 | 24 | 5 | 0 | 1 | 0 | 1 | .325 | .391 | .600 | .991 | ||
| 15 | | Cubs | 15 | 3/31/2025 | @ | W 18-3 | 48 | 18 | 21 | 6 | 1 | 4 | 18 | 10 | 1 | 7 | 0 | 0 | 60 | 41 | 11 | 0 | 1 | 0 | 0 | .438 | .533 | .854 | 1.388 | ||
| 16 | | Brewers | 14 | 8/12/2025 | vs | W 14-0 | 40 | 14 | 15 | 4 | 0 | 5 | 14 | 5 | 0 | 8 | 0 | 0 | 46 | 34 | 9 | 0 | 1 | 0 | 0 | .375 | .435 | .850 | 1.285 | ||
| 17 | | Blue Jays | 14 | 8/4/2025 | @ | W 15-1 | 50 | 15 | 25 | 4 | 1 | 3 | 15 | 3 | 0 | 5 | 0 | 0 | 53 | 40 | 8 | 0 | 0 | 0 | 2 | .500 | .528 | .800 | 1.328 | ||
| 18 |  | Red Sox | 14 | 6/28/2025 | vs | W 15-1 | 40 | 15 | 18 | 6 | 0 | 3 | 14 | 6 | 2 | 7 | 2 | 0 | 50 | 33 | 9 | 0 | 2 | 0 | 0 | .450 | .520 | .825 | 1.345 | ||
| 19 | | Orioles | 14 | 6/27/2025 | vs | W 22-8 | 46 | 22 | 21 | 9 | 1 | 4 | 20 | 8 | 1 | 9 | 2 | 0 | 55 | 44 | 14 | 0 | 0 | 0 | 0 | .457 | .545 | .957 | 1.502 | ||
| 20 | | Red Sox | 14 | 5/23/2025 | vs | W 19-5 | 45 | 19 | 20 | 6 | 0 | 3 | 19 | 8 | 0 | 7 | 0 | 0 | 53 | 35 | 9 | 0 | 0 | 0 | 1 | .444 | .528 | .778 | 1.306 | ||
| 21 | | Blue Jays | 14 | 5/21/2025 | vs | W 14-0 | 40 | 14 | 14 | 3 | 0 | 2 | 13 | 3 | 2 | 7 | 1 | 0 | 46 | 23 | 5 | 1 | 0 | 0 | 0 | .350 | .422 | .575 | .997 | ||
| 22 |  | Mets | 14 | 4/28/2025 | @ | W 19-5 | 47 | 19 | 21 | 3 | 1 | 4 | 19 | 6 | 2 | 9 | 0 | 0 | 56 | 38 | 8 | 0 | 1 | 0 | 0 | .447 | .518 | .809 | 1.326 | ||
| 23 | | Mariners | 14 | 4/26/2025 | vs | W 14-0 | 37 | 14 | 15 | 3 | 0 | 4 | 14 | 7 | 1 | 6 | 0 | 0 | 46 | 30 | 7 | 0 | 1 | 0 | 0 | .405 | .500 | .811 | 1.311 | ||
| 24 |  | Athletics | 13 | 9/6/2025 | @ | W 17-4 | 49 | 17 | 21 | 4 | 0 | 4 | 17 | 6 | 1 | 8 | 1 | 0 | 56 | 37 | 8 | 0 | 0 | 0 | 0 | .429 | .500 | .755 | 1.255 | ||
| 25 | | Red Sox | 13 | 8/12/2025 | @ | W 14-1 | 40 | 14 | 13 | 2 | 0 | 3 | 14 | 8 | 2 | 5 | 2 | 0 | 51 | 24 | 5 | 0 | 1 | 0 | 0 | .325 | .451 | .600 | 1.051 | ||
CIN
BAL
SDP
COL
KCR
TOR
TEX
LAA
HOU
LAD
ATH
SEA
ATL
NYY
CHC
PHI
TBR
BOS
MIL
PIT
NYM
WSH
MIASome of the information used here was obtained free of charge from Retrosheet.
More Reds Stats
Team Batting Leaders 
HR
3
De La Cruz
RBI
7
Suárez
AVG
.351
Stewart
Team Pitching Leaders 
W
1
Burns
K
16
Burns
ERA
0.82
Burns
Team Rankings
HR
10
17th
R
34
30th
SO
101
14th
ERA
2.82
5th
Cardinals
MLB 2026 Batting Leaders
MLB 2026 Pitching Leaders
MLB Fantasy 2026
MLB 2026 Betting
MLB 2026 Standings
| NL East | W | L | PCT | GB |
|---|---|---|---|---|
7 | 4 | .636 | ||
7 | 5 | .583 | 0.5 | |
6 | 5 | .545 | 1.0 | |
6 | 5 | .545 | 1.0 | |
4 | 7 | .364 | 3.0 | |
| NL Central | W | L | PCT | GB |
8 | 3 | .727 | ||
8 | 3 | .727 | ||
7 | 4 | .636 | 1.0 | |
6 | 5 | .545 | 2.0 | |
5 | 6 | .455 | 3.0 | |
| NL West | W | L | PCT | GB |
9 | 2 | .818 | ||
5 | 6 | .455 | 4.0 | |
5 | 6 | .455 | 4.0 | |
5 | 6 | .455 | 4.0 | |
4 | 8 | .333 | 5.5 |
Diamondbacks
Giants| AL East | W | L | PCT | GB |
|---|---|---|---|---|
8 | 2 | .800 | ||
5 | 6 | .455 | 3.5 | |
5 | 6 | .455 | 3.5 | |
4 | 7 | .364 | 4.5 | |
3 | 8 | .273 | 5.5 | |
| AL Central | W | L | PCT | GB |
7 | 5 | .583 | ||
5 | 6 | .455 | 1.5 | |
5 | 6 | .455 | 1.5 | |
4 | 7 | .364 | 2.5 | |
4 | 7 | .364 | 2.5 | |
| AL West | W | L | PCT | GB |
6 | 5 | .545 | ||
6 | 6 | .500 | 0.5 | |
6 | 6 | .500 | 0.5 | |
4 | 8 | .333 | 2.5 | |
3 | 7 | .300 | 2.5 |
Guardians
Twins
White Sox
Tigers
