Chris Sale has fanned the most career hitters by an active pitcher, with 2,579 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Chris Sale C. Sale	2,579	393	145	88	.622	312	3.01	16	3	12	2084.0	1,692	697	750	213	487	130	25	15	8,389	48	11.14	2.10	5.30	0.92	30.7	5.8	1.05	.297	3.24	70	2.87	68	7.31	303.3
2	Gerrit Cole G. Cole	2,251	317	153	80	.657	317	3.18	8	5	0	1954.0	1,627	690	740	217	500	61	0	8	7,861	58	10.37	2.30	4.50	1.00	28.6	6.4	1.09	.292	3.41	79	3.16	77	7.49	213.5
3	Yu Darvish Y. Darvish	2,075	297	115	93	.553	297	3.65	2	1	0	1778.0	1,460	721	756	231	563	83	0	8	7,305	83	10.50	2.85	3.69	1.17	28.4	7.7	1.14	.282	3.83	87	3.58	85	7.39	120
4	Kevin Gausman K. Gausman	1,954	361	112	113	.498	322	3.81	4	2	0	1911.0	1,835	810	866	233	535	38	11	11	7,986	64	9.20	2.52	3.65	1.10	24.5	6.7	1.24	.307	4.08	92	3.59	85	8.64	132.7
5	Sonny Gray S. Gray	1,925	339	125	102	.551	330	3.58	7	5	0	1918.0	1,675	763	836	192	621	57	2	5	7,952	106	9.03	2.91	3.10	0.90	24.2	7.8	1.20	.288	3.92	87	3.51	85	7.86	136.2
6	Aaron Nola A. Nola	1,876	285	109	89	.551	285	3.83	6	4	0	1715.2	1,522	730	769	217	449	56	0	16	7,039	18	9.84	2.36	4.18	1.14	26.7	6.4	1.15	.294	4.03	91	3.50	82	7.98	147.1
7	Jacob deGrom J. deGrom	1,851	248	96	65	.596	248	2.57	4	2	0	1539.2	1,173	440	477	146	345	25	0	13	6,045	30	10.82	2.02	5.37	0.85	30.6	5.7	0.99	.279	2.79	66	2.70	66	6.86	239.4
8	Zack Wheeler Z. Wheeler	1,820	283	113	75	.601	283	3.28	5	3	0	1728.1	1,475	630	683	166	490	76	0	14	7,086	41	9.48	2.55	3.71	0.86	25.7	6.9	1.14	.289	3.56	82	3.28	80	7.68	164.6
9	Robbie Ray R. Ray	1,734	265	88	81	.521	261	3.94	2	1	0	1441.0	1,250	631	674	216	608	51	1	19	6,097	60	10.83	3.80	2.85	1.35	28.4	10.0	1.29	.296	4.21	94	4.06	99	7.81	5.1
10	Luis Castillo L. Castillo	1,493	243	83	84	.497	243	3.55	1	0	0	1410.2	1,208	557	608	174	453	48	0	8	5,824	19	9.53	2.89	3.30	1.11	25.6	7.8	1.18	.283	3.88	86	3.72	88	7.71	78.1
11	Nathan Eovaldi N. Eovaldi	1,487	316	102	84	.548	297	3.89	5	3	0	1702.1	1,661	736	780	188	466	55	5	17	7,124	54	7.86	2.46	3.19	0.99	20.9	6.5	1.25	.299	4.12	95	3.75	92	8.78	66.2
12	José Berríos J. Berríos	1,481	275	108	82	.568	273	4.08	5	1	0	1571.2	1,474	713	765	219	473	98	0	7	6,607	35	8.48	2.71	3.13	1.25	22.4	7.2	1.24	.289	4.38	97	4.18	99	8.44	14.3
13	Blake Snell B. Snell	1,440	222	81	62	.566	222	3.15	1	1	0	1158.0	891	405	440	111	521	11	0	6	4,791	86	11.19	4.05	2.76	0.86	30.1	10.9	1.22	.288	3.42	77	3.31	79	6.92	111.7
14	Michael Wacha M. Wacha	1,416	309	110	75	.595	288	3.89	2	2	0	1627.1	1,571	703	746	194	503	42	4	18	6,846	43	7.83	2.78	2.82	1.07	20.7	7.3	1.27	.294	4.13	96	3.96	97	8.69	17.3
15	Carlos Rodón C. Rodón	1,409	231	93	72	.564	226	3.73	3	1	0	1282.0	1,085	532	574	159	477	65	1	5	5,378	65	9.89	3.35	2.95	1.12	26.2	8.9	1.22	.283	4.03	90	3.83	90	7.62	58.2
16	Aroldis Chapman A. Chapman	1,331	863	60	47	.561	0	2.52	0	0	367	821.1	475	230	255	54	408	33	563	7	3,341	87	14.58	4.47	3.26	0.59	39.8	12.2	1.08	.278	2.79	61	2.36	57	5.20	161.8
17	Nick Pivetta N. Pivetta	1,329	254	69	76	.476	209	4.47	2	0	3	1211.0	1,107	602	631	197	427	34	13	7	5,107	53	9.88	3.17	3.11	1.46	26.0	8.4	1.27	.292	4.69	105	4.22	100	8.23	1.1
18	Eduardo Rodriguez E. Rodriguez	1,297	241	94	66	.588	235	4.19	0	0	0	1304.2	1,280	607	641	167	455	32	1	9	5,579	17	8.95	3.14	2.85	1.15	23.2	8.2	1.33	.307	4.42	95	3.96	95	8.83	34.8
19	Sean Manaea S. Manaea	1,184	243	79	66	.545	210	4.08	3	3	0	1245.0	1,150	565	611	171	347	61	5	4	5,196	36	8.56	2.51	3.41	1.24	22.8	6.7	1.20	.285	4.42	100	4.02	98	8.31	14.6
20	Freddy Peralta F. Peralta	1,153	211	70	42	.625	162	3.59	1	0	1	931.0	694	371	392	118	360	48	6	3	3,853	31	11.15	3.48	3.20	1.14	29.9	9.3	1.13	.265	3.79	85	3.66	87	6.71	59.2
21	Jack Flaherty J. Flaherty	1,130	190	63	56	.529	184	3.80	0	0	0	990.2	836	418	440	135	351	54	0	10	4,120	35	10.27	3.19	3.22	1.23	27.4	8.5	1.20	.286	4.00	93	3.89	94	7.59	28.8
22	Corbin Burnes C. Burnes	1,114	210	63	38	.624	149	3.15	0	0	2	968.0	756	339	374	104	280	38	16	3	3,914	42	10.36	2.60	3.98	0.97	28.5	7.2	1.07	.274	3.48	75	3.25	78	7.03	100.7
23	Taijuan Walker T. Walker	1,088	251	77	71	.520	230	4.18	3	1	1	1278.0	1,211	594	654	186	434	58	7	13	5,423	27	7.66	3.06	2.51	1.31	20.1	8.0	1.29	.280	4.61	102	4.50	108	8.53	-46.3
24	Jameson Taillon J. Taillon	1,073	224	82	60	.577	223	3.87	3	1	1	1237.0	1,182	532	570	170	294	32	1	10	5,128	25	7.81	2.14	3.65	1.24	20.9	5.7	1.19	.284	4.15	95	4.00	97	8.60	18
25	Luis Severino L. Severino	1,073	201	73	55	.570	185	3.92	2	2	0	1072.0	975	467	509	136	325	54	4	3	4,488	30	9.01	2.73	3.30	1.14	23.9	7.2	1.21	.289	4.27	95	3.86	91	8.19	46.2