The Cleveland Guardians have the highest run differential by a team in their last 25 games, with a differential of 45 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Guardians	45	25	.760	19	6	810	106	187	48	4	25	102	80	5	210	21	5	903	318	77	5	3	5	12	.231	.303	.393	.695
2	Blue Jays	44	25	.600	15	10	893	143	245	49	5	37	137	83	13	178	6	4	1,003	415	91	7	7	8	15	.274	.342	.465	.807
3	Padres	32	25	.600	15	10	843	115	210	32	2	32	112	64	9	194	18	3	929	342	66	6	7	2	11	.249	.307	.406	.712
4	Dodgers	26	25	.760	19	6	881	111	205	36	4	40	106	89	15	240	5	2	996	369	80	7	4	16	12	.233	.312	.419	.731
5	Phillies	26	25	.600	15	10	847	119	213	44	4	39	118	82	8	234	14	7	951	382	87	3	11	6	12	.251	.320	.451	.771
6	Mariners	22	25	.600	15	10	850	121	207	38	2	43	116	87	15	255	21	3	961	378	83	2	7	7	21	.244	.322	.445	.767
7	Yankees	22	25	.680	17	8	834	126	221	40	1	35	123	97	12	250	19	8	952	368	76	0	9	11	18	.265	.347	.441	.788
8	Cubs	21	25	.560	14	11	824	106	207	35	4	40	100	78	7	231	18	8	919	370	79	4	6	5	12	.251	.319	.449	.768
9	Royals	17	25	.480	12	13	849	122	213	50	3	27	118	76	11	164	12	3	944	350	80	2	6	1	13	.251	.318	.412	.731
10	Giants	10	25	.520	13	12	825	125	189	34	3	33	121	93	10	207	6	5	939	328	70	0	11	5	14	.229	.311	.398	.709
11	Braves	7	25	.560	14	11	845	120	211	36	5	36	117	83	7	188	14	6	944	365	77	1	8	0	17	.250	.319	.432	.751
12	Astros	6	25	.480	12	13	862	114	205	41	1	31	108	67	13	221	19	4	946	341	73	1	3	2	14	.238	.302	.396	.697
13	Athletics	4	25	.520	13	12	860	114	219	50	0	32	108	68	9	225	13	4	944	365	82	4	3	1	10	.255	.315	.424	.739
14	Red Sox	-1	25	.480	12	13	852	97	209	45	3	18	91	74	6	214	22	3	941	314	66	3	6	3	22	.245	.308	.369	.677
15	White Sox	-3	25	.440	11	14	830	111	190	37	1	29	109	71	14	229	7	1	923	316	67	3	5	0	18	.229	.299	.381	.680
16	Pirates	-3	25	.400	10	15	830	85	179	40	3	18	82	86	9	233	13	6	927	279	61	0	2	1	16	.216	.296	.336	.632
17	Brewers	-4	25	.440	11	14	822	92	188	37	3	19	89	90	10	204	18	5	935	288	59	3	10	1	16	.229	.309	.350	.659
18	Reds	-5	25	.520	13	12	824	100	183	27	2	29	97	84	5	235	14	2	920	301	58	0	7	1	16	.222	.296	.365	.661
19	Marlins	-6	25	.560	14	11	858	110	210	42	3	23	108	71	13	171	26	8	950	327	68	0	8	1	12	.245	.309	.381	.691
20	Rangers	-10	25	.440	11	14	844	97	179	34	3	22	93	76	7	213	19	4	935	285	59	3	5	1	16	.212	.281	.338	.619
21	Diamondbacks	-12	25	.480	12	13	840	115	215	41	5	25	108	84	12	207	21	9	957	341	71	10	11	5	17	.256	.328	.406	.734
22	Mets	-13	25	.400	10	15	849	116	207	36	1	36	112	80	10	228	29	5	950	353	73	4	7	3	13	.244	.314	.416	.730
23	Orioles	-23	25	.560	14	11	808	82	161	27	2	27	80	99	9	263	26	6	921	273	56	1	4	4	10	.199	.292	.338	.630
24	Rays	-24	25	.360	9	16	838	93	213	34	1	26	91	75	4	223	21	4	927	327	61	4	6	1	23	.254	.316	.390	.707
25	Tigers	-30	25	.320	8	17	869	80	189	32	2	23	78	82	9	263	5	2	969	294	57	4	5	6	12	.217	.290	.338	.628