The New York Yankees have the highest run differential by a team, with a differential of 13,142 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,142	19,072	.570	10,814	8,170	650,021	92,686	172,568	28,657	5,497	17,336	86,123	68,639	4,933	94,933	11,659	2,803	736,478	264,227	51,490	9,595	3,290	2,838	10,690	.265	.339	.406	.745
2	Giants	7,476	21,782	.535	11,574	10,045	743,382	100,699	195,520	31,361	7,039	15,595	90,171	68,338	5,680	99,672	16,525	3,147	832,082	287,744	53,995	11,667	3,015	4,018	10,194	.263	.329	.387	.716
3	Dodgers	6,262	21,698	.532	11,468	10,091	739,337	97,987	193,181	31,078	7,006	14,152	88,205	68,947	5,153	100,439	17,347	3,553	829,351	280,727	52,236	12,774	3,064	3,738	9,954	.261	.327	.380	.707
4	Cubs	3,618	22,314	.513	11,364	10,789	763,623	102,761	199,995	33,779	7,361	15,264	88,346	68,611	5,287	105,136	15,808	3,074	853,459	294,288	56,404	13,027	2,911	3,523	9,971	.262	.326	.385	.711
5	Red Sox	3,590	19,362	.518	9,984	9,295	662,681	90,415	176,818	33,140	5,600	14,615	83,849	66,846	4,808	95,687	9,639	2,552	748,272	265,003	53,355	10,597	3,340	2,999	11,552	.267	.337	.400	.737
6	Guardians	2,247	19,370	.513	9,884	9,395	660,182	87,568	174,761	31,164	5,500	13,928	80,931	62,662	4,840	94,689	11,916	3,390	742,507	258,709	50,592	11,464	3,359	2,548	10,534	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,957	20,665	.513	10,538	9,996	706,854	92,457	187,835	31,847	7,052	12,867	84,517	64,220	5,206	98,245	15,018	3,617	791,399	272,387	51,766	11,974	3,145	3,776	10,143	.266	.330	.385	.715
9	Braves	1,538	22,275	.504	11,141	10,980	762,652	99,553	198,072	32,124	6,301	15,067	86,599	67,539	5,070	100,242	14,102	3,069	850,827	287,999	53,492	12,685	2,881	3,655	10,389	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	766	21,899	.504	10,963	10,797	746,159	98,263	194,402	32,404	7,561	14,334	87,404	66,745	5,508	102,380	18,169	3,410	834,283	284,930	54,299	12,662	3,041	3,647	9,725	.261	.325	.382	.707
13	Astros	721	10,038	.502	5,041	4,992	340,645	42,805	86,844	15,919	2,173	8,440	40,286	32,377	2,908	63,005	7,154	3,136	382,677	132,429	26,532	4,030	2,717	3,145	7,420	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	381	7,611	.498	3,792	3,816	260,758	35,187	67,818	13,552	1,492	8,274	33,376	24,195	2,428	49,038	4,579	1,963	291,014	109,176	23,318	1,504	2,129	1,404	5,937	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	342	19,396	.503	9,715	9,588	661,417	89,066	174,730	29,609	6,297	14,588	82,017	65,584	4,452	96,841	11,293	2,938	745,572	260,697	50,494	11,009	3,110	2,448	10,722	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331