Since 2017, the Los Angeles Dodgers have the highest run differential by a team, with a differential of 1,833 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	1,833	1,261	.634	799	462	42,796	6,601	10,874	2,287	191	1,886	6,328	4,843	568	10,665	684	165	48,762	19,201	4,364	181	374	276	813	.254	.335	.449	.784
2	Astros	1,410	1,258	.600	755	503	42,932	6,320	11,255	2,264	149	1,712	6,074	4,191	512	9,204	632	213	48,102	18,953	4,125	93	374	162	1,042	.262	.332	.441	.774
3	Yankees	1,128	1,258	.583	733	525	42,302	6,322	10,498	1,927	130	1,945	6,045	4,793	465	10,914	636	194	47,999	18,520	4,002	87	352	178	964	.248	.329	.438	.767
4	Braves	830	1,257	.559	703	554	42,921	6,183	10,990	2,233	162	1,762	5,939	4,105	494	10,766	662	208	47,994	18,833	4,157	184	290	249	848	.256	.326	.439	.765
5	Rays	675	1,259	.561	706	553	42,543	5,742	10,489	2,111	219	1,483	5,448	4,155	577	11,419	969	321	47,665	17,487	3,813	84	306	142	795	.247	.320	.411	.731
6	Guardians	662	1,257	.553	695	562	42,293	5,688	10,506	2,161	177	1,415	5,407	4,003	515	9,561	928	245	47,337	17,266	3,753	176	350	230	849	.248	.319	.408	.727
7	Brewers	508	1,261	.556	701	560	42,309	5,762	10,248	1,982	157	1,581	5,497	4,518	517	11,505	977	249	47,784	17,287	3,720	164	276	209	908	.242	.321	.409	.730
8	Cubs	425	1,260	.521	656	604	42,432	5,942	10,505	2,045	228	1,543	5,667	4,370	635	11,128	759	256	47,964	17,635	3,816	216	311	234	886	.248	.325	.416	.740
9	Red Sox	405	1,261	.531	670	591	43,655	6,271	11,375	2,579	177	1,535	5,962	4,117	476	10,722	735	226	48,651	18,913	4,291	85	318	233	942	.261	.329	.433	.762
10	Twins	299	1,259	.520	655	604	42,822	5,982	10,721	2,217	168	1,659	5,718	4,143	560	10,786	460	168	47,936	18,251	4,044	97	314	141	864	.250	.322	.426	.749
11	Cardinals	277	1,257	.529	665	592	42,237	5,694	10,514	2,042	148	1,489	5,437	4,157	577	10,342	692	220	47,531	17,319	3,679	220	340	174	851	.249	.322	.410	.732
12	Mets	154	1,260	.510	643	617	42,405	5,686	10,505	2,048	180	1,574	5,469	4,095	718	10,407	599	192	47,681	17,635	3,802	179	284	195	929	.248	.322	.416	.738
13	Phillies	92	1,259	.513	646	613	42,625	5,805	10,594	2,122	217	1,546	5,559	4,194	468	11,000	770	192	47,762	17,788	3,885	179	296	223	841	.249	.321	.417	.738
14	Diamondbacks	59	1,259	.488	615	644	42,615	5,923	10,484	2,199	289	1,459	5,636	4,272	498	10,548	775	192	47,988	17,638	3,947	251	352	194	849	.246	.320	.414	.733
15	Blue Jays	-45	1,259	.500	629	630	42,680	5,744	10,669	2,239	119	1,645	5,509	4,028	441	10,178	540	195	47,528	18,081	4,003	101	278	111	967	.250	.319	.424	.743
16	Mariners	-56	1,258	.515	648	610	42,233	5,542	10,072	1,931	141	1,549	5,311	4,191	657	11,306	801	262	47,477	16,932	3,621	106	290	117	827	.238	.315	.401	.716
17	Giants	-103	1,260	.498	628	632	42,580	5,377	10,260	2,098	193	1,345	5,150	4,019	475	11,030	515	186	47,581	16,779	3,636	172	335	209	910	.241	.311	.394	.705
18	Padres	-106	1,258	.496	624	634	42,111	5,433	10,246	1,974	176	1,449	5,184	4,106	421	10,576	774	253	47,192	16,919	3,599	255	299	179	901	.243	.315	.402	.717
19	Nationals	-271	1,259	.469	590	669	42,414	5,718	10,818	2,182	189	1,370	5,450	4,023	531	9,764	914	286	47,527	17,488	3,741	251	308	235	944	.255	.325	.412	.737
20	Reds	-385	1,260	.459	578	682	42,143	5,610	10,268	1,977	197	1,529	5,369	4,144	656	11,071	854	290	47,442	17,226	3,703	218	281	154	880	.244	.319	.409	.728
21	Rangers	-398	1,260	.454	572	688	42,442	5,687	10,234	1,969	161	1,556	5,401	3,946	494	11,173	835	261	47,303	17,193	3,686	124	297	118	772	.241	.311	.405	.716
22	Athletics	-462	1,261	.473	596	665	42,263	5,499	10,041	2,109	151	1,572	5,247	4,120	555	11,021	617	175	47,358	17,168	3,832	118	302	107	950	.238	.312	.406	.718
23	Angels	-559	1,258	.456	574	684	42,281	5,484	10,155	1,915	168	1,574	5,242	3,938	541	10,759	700	239	47,166	17,128	3,657	115	291	205	916	.240	.311	.405	.716
24	White Sox	-798	1,259	.424	534	725	42,609	5,239	10,502	2,005	159	1,341	5,015	3,348	491	11,147	590	206	46,886	16,848	3,505	180	258	97	923	.246	.307	.395	.702
25	Orioles	-824	1,258	.440	554	704	42,823	5,540	10,562	2,069	169	1,564	5,307	3,551	489	10,908	623	195	47,283	17,661	3,802	115	305	98	848	.247	.310	.412	.722