The Cleveland Guardians had a record of 31-35 against the Astros between September 18, 2014 and September 30, 2025.
| OPP | REC | W% | G | W | L | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Astros | 31-35 | .470 | 66 | 31 | 35 | 2,236 | 244 | 512 | 119 | 11 | 69 | 233 | 206 | 16 | 558 | 33 | 12 | 2,488 | 860 | 199 | 14 | 16 | 8 | 49 | .229 | .297 | .385 | .681 |
| 2 |  Twins | 101-84 | .546 | 185 | 101 | 84 | 6,329 | 797 | 1,559 | 302 | 25 | 220 | 757 | 579 | 73 | 1,396 | 122 | 24 | 7,052 | 2,571 | 547 | 21 | 50 | 41 | 113 | .246 | .314 | .406 | .721 |
| 3 |  Royals | 111-74 | .600 | 185 | 111 | 74 | 6,233 | 904 | 1,648 | 347 | 30 | 219 | 863 | 620 | 76 | 1,269 | 107 | 35 | 7,030 | 2,712 | 596 | 36 | 65 | 30 | 138 | .264 | .335 | .435 | .770 |
| 4 |  Rays | 35-34 | .507 | 69 | 35 | 34 | 2,267 | 247 | 507 | 91 | 8 | 59 | 234 | 186 | 24 | 606 | 61 | 10 | 2,505 | 791 | 158 | 11 | 17 | 16 | 32 | .224 | .287 | .349 | .636 |
| 5 |  Tigers | 113-67 | .628 | 180 | 113 | 67 | 6,085 | 898 | 1,607 | 350 | 49 | 204 | 867 | 591 | 66 | 1,283 | 113 | 31 | 6,830 | 2,667 | 603 | 26 | 62 | 33 | 133 | .264 | .333 | .438 | .771 |
| 6 |  White Sox | 108-74 | .593 | 182 | 108 | 74 | 6,041 | 795 | 1,482 | 317 | 25 | 206 | 753 | 602 | 72 | 1,404 | 141 | 29 | 6,800 | 2,467 | 548 | 30 | 55 | 24 | 129 | .245 | .318 | .408 | .727 |
| 7 |  Blue Jays | 38-29 | .567 | 67 | 38 | 29 | 2,290 | 308 | 579 | 125 | 6 | 69 | 298 | 208 | 22 | 523 | 50 | 12 | 2,545 | 923 | 200 | 9 | 16 | 11 | 48 | .253 | .319 | .403 | .722 |
| 8 |  Rangers | 37-26 | .587 | 63 | 37 | 26 | 2,164 | 347 | 585 | 120 | 11 | 76 | 333 | 204 | 39 | 446 | 71 | 14 | 2,436 | 955 | 207 | 8 | 21 | 12 | 48 | .270 | .341 | .441 | .782 |
| 9 |  Mariners | 32-34 | .485 | 66 | 32 | 34 | 2,214 | 245 | 504 | 101 | 4 | 62 | 226 | 181 | 23 | 529 | 41 | 13 | 2,444 | 799 | 167 | 5 | 21 | 16 | 50 | .228 | .290 | .361 | .651 |
| 10 |  Orioles | 37-30 | .552 | 67 | 37 | 30 | 2,244 | 306 | 575 | 123 | 8 | 69 | 291 | 215 | 23 | 465 | 41 | 16 | 2,509 | 921 | 200 | 7 | 20 | 12 | 48 | .256 | .325 | .410 | .735 |
| 11 |  Athletics | 36-28 | .563 | 64 | 36 | 28 | 2,141 | 289 | 530 | 135 | 9 | 57 | 265 | 200 | 21 | 495 | 55 | 23 | 2,399 | 854 | 201 | 11 | 26 | 10 | 46 | .248 | .314 | .399 | .713 |
| 12 |  Angels | 44-19 | .698 | 63 | 44 | 19 | 2,100 | 314 | 555 | 111 | 4 | 88 | 302 | 221 | 24 | 455 | 58 | 16 | 2,376 | 938 | 203 | 10 | 21 | 21 | 43 | .264 | .338 | .447 | .785 |
| 13 |  Yankees | 29-37 | .439 | 66 | 29 | 37 | 2,244 | 289 | 526 | 100 | 9 | 80 | 269 | 221 | 19 | 603 | 51 | 13 | 2,506 | 884 | 189 | 8 | 14 | 6 | 45 | .234 | .307 | .394 | .701 |
| 14 |  Red Sox | 30-34 | .469 | 64 | 30 | 34 | 2,189 | 302 | 566 | 120 | 8 | 76 | 288 | 195 | 28 | 505 | 53 | 13 | 2,440 | 930 | 204 | 14 | 14 | 12 | 48 | .259 | .325 | .425 | .750 |
Some of the information used here was obtained free of charge from Retrosheet.
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