The 2021 roster for the Indians included Cal Quantrill at pitcher, Austin Hedges at catcher, Bobby Bradley at first baseman, Cesar Hernandez at second baseman and José Ramírez at third baseman.

	NO.	NAME	POS	HEIGHT	WEIGHT	DOB	AGE	BIRTHPLACE
1	54	Logan Allen L. Allen	P	6'3"	200	5/23/1997	24	West Palm Beach, FL
2	71	Gabriel Arias G. Arias	SS	6'1"	201	2/27/2000	21	La Victoria, Venezuela
3	10	Jake Bauers J. Bauers	1B	6'1"	195	10/6/1995	25	Newport Beach, CA
4	57	Shane Bieber S. Bieber	P	6'3"	200	5/31/1995	26	Orange, CA
5	44	Bobby Bradley B. Bradley	1B	6'1"	225	5/29/1996	25	Gulfport, MS
6	2	Yu Chang Y. Chang	1B	6'1"	180	8/18/1995	25	Taitung, Taiwan
7	43	Aaron Civale A. Civale	P	6'2"	215	6/12/1995	26	East Windsor, CT
8	48	Emmanuel Clase E. Clase	P	6'2"	206	3/18/1998	23	Rio San Juan, Dominican Republic
9	28	Ernie Clement E. Clement	2B	6'0"	170	3/22/1996	25	Rochester, NY
10	28	Ben Gamel B. Gamel	CF	5'11"	185	5/17/1992	29	Neptune Beach, FL
11	63	Justin Garza J. Garza	P	5'10"	170	3/20/1994	27	Glendora, CA
12	0	Andrés Giménez A. Giménez	SS	6'0"	161	9/4/1998	22	Barquisimeto, Venezuela
13	26	Anthony Gose A. Gose	P	6'1"	190	8/10/1990	30	Bellflower, CA
14	17	Austin Hedges A. Hedges	C	6'1"	206	8/18/1992	28	San Juan Capistrano, CA
15	31	Sam Hentges S. Hentges	P	6'8"	245	7/18/1996	24	Shoreview, MN
16	7	Cesar Hernandez C. Hernandez	2B	5'10"	160	5/23/1990	31	Valencia, Venezuela
17	65	Cam Hill C. Hill	P	6'1"	185	5/24/1994	27	Oklahoma City, OK
18	56	DJ Johnson	P	6'4"	230	8/30/1989	31	Beaverton, OR
19	23	Daniel Johnson D. Johnson	RF	5'10"	200	7/11/1995	25	Vallejo, CA
20	95	Nolan Jones N. Jones	3B	6'2"	185	5/7/1998	23	Langhorne, PA
21	99	James Karinchak J. Karinchak	P	6'3"	230	9/22/1995	25	Walden, NY
22	50	Ryan Lavarnway R. Lavarnway	C	6'4"	240	8/7/1987	33	Woodland Hills, CA
23	8	Jordan Luplow J. Luplow	CF	6'1"	195	9/26/1993	27	Visalia, CA
24	88	Phil Maton P. Maton	P	6'3"	220	3/25/1993	28	Paducah, KY
25	24	Triston McKenzie T. McKenzie	P	6'5"	165	8/2/1997	23	Brooklyn, NY