Chuck Klein has hit the fewest career home runs with 300+ home runs, with 300 home runs.

Interpreted as:

fastest to 300 or more home runs by a player career

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Chuck Klein C. Klein	300	1,753	6,486	1,168	2,076	398	74	1,201	601	12	521	79		7,168	3,522	772	69			15	.320	.379	.543	.922	1310	404.5	.411	133	313.3
2	Rogers Hornsby R. Hornsby	301	2,259	8,173	1,579	2,930	541	169	1,584	1,038	48	679	135		9,475	4,712	1,011	216				.358	.434	.577	1.010	2018	899	.459	173	863.2
3	Anthony Rizzo A. Rizzo	303	1,727	6,288	922	1,644	338	22	965	781	222	1,208	72	44	7,336	2,935	663	0	45	75	149	.261	.361	.467	.828	1103	246.1	.356	125	223.8
4	Steve Finley S. Finley	304	2,583	9,397	1,443	2,548	449	124	1,167	844	53	1,299	320	118	10,460	4,157	877	91	75	69	152	.271	.332	.442	.775	1343	67.9	.336	104	48.5
5	Raul Ibanez R. Ibanez	305	2,161	7,471	1,055	2,034	424	51	1,207	713	29	1,374	50	29	8,278	3,475	780	2	63	83	166	.272	.335	.465	.801	1115	124.5	.344	110	104.9
6	Reggie Sanders R. Sanders	305	1,777	6,241	1,037	1,666	341	60	983	674	71	1,614	304	115	7,043	3,042	706	14	43	49	121	.267	.343	.487	.830	1026	157.8	.357	115	135.9
7	David Justice D. Justice	305	1,610	5,625	929	1,571	280	24	1,017	903	18	999	53	46	6,601	2,814	609	1	54	85	101	.279	.378	.500	.878	1080	278.3	.380	130	244.9
8	Richie Sexson R. Sexson	306	1,367	4,928	748	1,286	260	17	943	588	52	1,313	14	13	5,604	2,498	583	0	36	31	144	.261	.344	.507	.851	847	150.6	.363	119	132.6
9	Ruben Sierra R. Sierra	306	2,186	8,044	1,084	2,152	428	59	1,322	610	7	1,239	142	52	8,782	3,616	793	1	120	102	193	.268	.315	.450	.765	1073	37.3	.330	101	4.3
10	Fred Lynn F. Lynn	306	1,969	6,925	1,063	1,960	388	43	1,111	857	30	1,116	72	54	7,923	3,352	737	25	86	77	149	.283	.360	.484	.845	1215	326.8	.372	129	268.5
11	Miguel Tejada M. Tejada	307	2,171	8,434	1,230	2,407	468	23	1,302	553	122	1,079	85	38	9,203	3,842	798	23	71	73	277	.285	.336	.456	.791	1218	91.7	.341	107	76.9
12	Greg Luzinski G. Luzinski	307	1,821	6,505	880	1,795	344	24	1,128	845	84	1,495	37	31	7,514	3,108	675	1	79	95	147	.276	.363	.478	.840	1141	317.2	.373	131	262.9
13	Al Simmons A. Simmons	307	2,215	8,759	1,507	2,927	539	149	1,828	615	30	737	88		9,515	4,685	995	111			23	.334	.380	.535	.915	1714	519.5	.410	130	400.1
14	Edgar Martinez E. Martinez	309	2,055	7,213	1,219	2,247	514	15	1,261	1,283	89	1,202	49	30	8,672	3,718	838	10	77	113	190	.312	.418	.515	.933	1606	548.2	.405	147	523.9
15	Jay Buhner J. Buhner	310	1,472	5,013	797	1,273	233	19	965	792	56	1,406	6	24	5,927	2,474	562	12	54	41	123	.254	.359	.494	.852	925	208.8	.371	124	177.9
16	Ivan Rodriguez I. Rodriguez	311	2,543	9,592	1,354	2,844	572	51	1,332	513	58	1,474	127	64	10,270	4,451	934	31	76	67	337	.296	.334	.464	.798	1383	124.8	.344	104	63.1
17	Reggie Smith R. Smith	314	1,987	7,033	1,123	2,020	363	57	1,092	890	33	1,030	137	86	8,050	3,439	734	8	86	115	150	.287	.366	.489	.855	1254	395	.379	137	333.7
18	Jeromy Burnitz J. Burnitz	315	1,694	5,710	917	1,447	298	29	981	739	78	1,376	74	58	6,579	2,748	642	9	43	75	99	.253	.345	.481	.826	944	124.7	.354	110	85
19	Matt Holliday M. Holliday	316	1,903	7,009	1,157	2,096	468	32	1,220	802	124	1,362	108	37	7,981	3,576	816	1	45	57	220	.299	.379	.510	.889	1333	395.2	.383	135	336.3
20	Scott Rolen S. Rolen	316	2,038	7,398	1,211	2,077	517	43	1,287	899	127	1,410	118	49	8,518	3,628	876	1	93	57	150	.281	.364	.490	.855	1321	276.8	.368	122	242.1
21	Ron Cey R. Cey	316	2,073	7,162	977	1,868	328	21	1,139	1,012	62	1,235	24	29	8,344	3,186	665	26	82	117	185	.261	.354	.445	.799	1161	232.3	.356	122	213
22	Adrian Gonzalez A. Gonzalez	317	1,929	7,139	997	2,050	437	12	1,202	782	45	1,401	6	7	8,043	3,462	766	4	73	158	207	.287	.358	.485	.843	1186	248.6	.359	126	255.2
23	George Brett G. Brett	317	2,707	10,349	1,583	3,154	665	137	1,596	1,096	33	908	201	97	11,624	5,044	1,119	26	120	229	235	.305	.369	.487	.857	1799	496.2	.374	132	436.3
24	Roy Sievers R. Sievers	318	1,887	6,387	945	1,703	292	42	1,147	841	51	920	14	11	7,349	3,033	652	15	55	55	164	.267	.354	.475	.829	1088	245.7	.367	121	187
25	Jay Bruce J. Bruce	319	1,650	5,964	839	1,455	312	32	951	600	28	1,572	65	40	6,641	2,788	663	3	46	71	101	.244	.314	.467	.781	847	79.1	.332	106	47.7