Lou Gehrig has the highest career OPS by a first baseman, with an OPS of 1.080.

Interpreted as:

highest carrer ops with a minimum of 3000 PA by a first baseman

	NAME	OPS	PA	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	WRC	WRAA	WOBA	WRC+	BRAA
1	Lou Gehrig L. Gehrig	1.080	9,660	2,164	8,001	1,888	2,721	534	163	493	1,995	1,508	45	790	102		5,060	1,190	106			2	.340	.447	.632	2265	1,046.8	.477	173	980
2	Frank Thomas F. Thomas	1.061	4,089	918	3,262	681	1,083	215	6	225	745	741	25	470	17	13	1,985	446	0	61	105	103	.332	.452	.609	897	403.1	.449	177	396
3	Jimmie Foxx J. Foxx	1.044	9,131	2,148	7,673	1,656	2,498	425	114	521	1,836	1,389	12	1,256	83		4,714	1,060	57			69	.326	.430	.614	2036	900.3	.463	159	752
4	Hank Greenberg H. Greenberg	1.012	5,030	1,148	4,282	859	1,331	304	60	275	1,052	701	15	717	48		2,580	639	32			41	.311	.410	.603	1054	447.6	.451	152	358.3
5	Mark McGwire M. McGwire	.985	7,602	1,856	6,134	1,157	1,616	251	6	580	1,405	1,313	74	1,578	12	7	3,619	837	3	78	150	147	.263	.395	.590	1475	566.5	.416	158	559.7
6	Jim Thome J. Thome	.984	5,292	1,238	4,272	836	1,190	229	12	337	909	947	32	1,338	4	9	2,454	578	0	41	107	64	.279	.410	.574	1026	365.8	.414	150	336.9
7	Stan Musial S. Musial	.959	4,894	1,145	4,237	709	1,388	270	58	183	732	593	24	254	24	7	2,323	511	14	26	90	111	.328	.411	.548	915	356.5	.423	151	304.9
8	Johnny Mize J. Mize	.959	7,371	1,884	6,443	1,118	2,011	367	83	359	1,337	856	52	524	28	0	3,621	809	20			76	.312	.397	.562	1421	546.3	.433	157	508.1
9	Todd Helton T. Helton	.955	9,349	2,212	7,869	1,388	2,493	590	36	364	1,395	1,327	57	1,164	37	28	4,247	990	3	93	185	185	.317	.415	.540	1750	610.4	.406	132	390.6
10	Jeff Bagwell J. Bagwell	.948	9,431	2,150	7,797	1,517	2,314	488	32	449	1,529	1,401	128	1,558	202	78	4,213	969	3	102	155	221	.297	.408	.540	1755	596.6	.405	149	588.3
11	Carlos Delgado C. Delgado	.944	7,834	1,815	6,573	1,149	1,863	450	16	436	1,385	1,019	160	1,534	13	7	3,653	902	0	82	180	133	.283	.388	.556	1402	429.9	.396	139	394.7
12	Dan Brouthers D. Brouthers	.944	7,388	1,608	6,441	1,463	2,210	442	196	98	994	822	105	83	256		3,338	736	20				.343	.426	.518	1810	703.6	.437	155	632.9
13	Jason Giambi J. Giambi	.939	6,942	1,745	5,626	987	1,598	314	7	352	1,147	1,101	142	1,212	15	9	2,982	673	1	72	78	129	.284	.409	.530	1284	425.9	.403	145	401.8
14	Miguel Cabrera M. Cabrera	.933	5,266	1,235	4,585	727	1,436	307	6	239	836	609	27	869	14	9	2,472	552	0	45	124	166	.313	.393	.539	929	318.6	.395	147	294.1
15	Albert Pujols A. Pujols	.931	8,925	2,096	7,766	1,332	2,307	479	9	494	1,485	999	76	899	100	32	4,286	982	0	84	265	291	.297	.379	.552	1554	497.4	.389	144	489.6
16	Lance Berkman L. Berkman	.928	3,684	886	3,064	513	882	194	10	173	571	570	26	613	44	16	1,615	377	0	24	87	87	.288	.401	.527	650	204.7	.394	141	190.9
17	Joey Votto J. Votto	.920	8,746	2,056	7,252	1,171	2,135	459	22	356	1,144	1,365	81	1,640	80	29	3,706	837	0	48	147	168	.294	.409	.511	1563	539.6	.394	145	472.9
18	Prince Fielder P. Fielder	.910	5,790	1,364	4,882	755	1,389	277	10	288	886	751	106	1,004	18	11	2,550	575	0	51	149	125	.285	.388	.522	977	298.5	.386	139	272.2
19	Mo Vaughn M. Vaughn	.906	6,410	1,512	5,532	861	1,620	270	10	328	1,064	725	108	1,429	30	18	2,894	608	0	45	144	136	.293	.383	.523	1090	296	.387	129	246.2
20	Dick Allen D. Allen	.903	3,481	846	3,000	505	846	152	21	183	574	443	8	736	70	27	1,589	356	3	27	60	93	.282	.373	.530	589	215	.399	150	191.7
21	Bill Terry B. Terry	.899	7,111	1,721	6,428	1,120	2,193	373	112	154	1,078	537	9	449	56		3,252	639	137				.341	.393	.506	1265	365	.407	136	346.7
22	Freddie Freeman F. Freeman	.898	9,033	2,102	7,820	1,340	2,348	529	32	352	1,274	1,039	110	1,694	98	31	3,997	913	0	64	140	166	.300	.387	.511	1546	492.5	.382	142	459.5
23	Roger Connor R. Connor	.892	7,979	1,799	6,980	1,469	2,203	395	221	131	1,071	951	39	151	244		3,433	747	9				.316	.401	.492	1773	571.8	.414	142	519.1
24	Hal Trosky Sr. H. Trosky Sr.	.892	5,747	1,347	5,161	835	1,561	331	58	228	1,012	545	16	440	28		2,692	617	25			43	.302	.371	.522	992	291.2	.402	126	210.9
25	Willie McCovey W. McCovey	.892	8,364	2,215	7,040	1,030	1,906	314	39	439	1,345	1,205	53	1,323	20	17	3,615	792	4	62	249	151	.271	.378	.513	1379	478.9	.389	145	432