Lou Gehrig has the highest career slugging percentage by a first baseman, with a slugging percentage of .632.

Interpreted as:

highest carrer slg with a minimum of 3000 PA by a first baseman

	NAME	SLG	PA	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Lou Gehrig L. Gehrig	.632	9,660	2,164	8,001	1,888	2,721	534	163	493	1,995	1,508	45	790	102		5,060	1,190	106			2	.340	.447	1.080	2265	1,046.8	.477	173	980
2	Jimmie Foxx J. Foxx	.614	9,131	2,148	7,673	1,656	2,498	425	114	521	1,836	1,389	12	1,256	83		4,714	1,060	57			69	.326	.430	1.044	2036	900.3	.463	159	752
3	Frank Thomas F. Thomas	.609	4,089	918	3,262	681	1,083	215	6	225	745	741	25	470	17	13	1,985	446	0	61	105	103	.332	.452	1.061	897	403.1	.449	177	396
4	Hank Greenberg H. Greenberg	.603	5,030	1,148	4,282	859	1,331	304	60	275	1,052	701	15	717	48		2,580	639	32			41	.311	.410	1.012	1054	447.6	.451	152	358.3
5	Mark McGwire M. McGwire	.590	7,602	1,856	6,134	1,157	1,616	251	6	580	1,405	1,313	74	1,578	12	7	3,619	837	3	78	150	147	.263	.395	.985	1475	566.5	.416	158	559.7
6	Jim Thome J. Thome	.574	5,292	1,238	4,272	836	1,190	229	12	337	909	947	32	1,338	4	9	2,454	578	0	41	107	64	.279	.410	.984	1026	365.8	.414	150	336.9
7	Johnny Mize J. Mize	.562	7,371	1,884	6,443	1,118	2,011	367	83	359	1,337	856	52	524	28	0	3,621	809	20			76	.312	.397	.959	1421	546.3	.433	157	508.1
8	Carlos Delgado C. Delgado	.556	7,834	1,815	6,573	1,149	1,863	450	16	436	1,385	1,019	160	1,534	13	7	3,653	902	0	82	180	133	.283	.388	.944	1402	429.9	.396	139	394.7
9	Albert Pujols A. Pujols	.552	8,925	2,096	7,766	1,332	2,307	479	9	494	1,485	999	76	899	100	32	4,286	982	0	84	265	291	.297	.379	.931	1554	497.4	.389	144	489.6
10	Stan Musial S. Musial	.548	4,894	1,145	4,237	709	1,388	270	58	183	732	593	24	254	24	7	2,323	511	14	26	90	111	.328	.411	.959	915	356.5	.423	151	304.9
11	Jeff Bagwell J. Bagwell	.540	9,431	2,150	7,797	1,517	2,314	488	32	449	1,529	1,401	128	1,558	202	78	4,213	969	3	102	155	221	.297	.408	.948	1755	596.6	.405	149	588.3
12	Todd Helton T. Helton	.540	9,349	2,212	7,869	1,388	2,493	590	36	364	1,395	1,327	57	1,164	37	28	4,247	990	3	93	185	185	.317	.415	.955	1750	610.4	.406	132	390.6
13	Miguel Cabrera M. Cabrera	.539	5,266	1,235	4,585	727	1,436	307	6	239	836	609	27	869	14	9	2,472	552	0	45	124	166	.313	.393	.933	929	318.6	.395	147	294.1
14	Jason Giambi J. Giambi	.530	6,942	1,745	5,626	987	1,598	314	7	352	1,147	1,101	142	1,212	15	9	2,982	673	1	72	78	129	.284	.409	.939	1284	425.9	.403	145	401.8
15	Dick Allen D. Allen	.530	3,481	846	3,000	505	846	152	21	183	574	443	8	736	70	27	1,589	356	3	27	60	93	.282	.373	.903	589	215	.399	150	191.7
16	Lance Berkman L. Berkman	.527	3,684	886	3,064	513	882	194	10	173	571	570	26	613	44	16	1,615	377	0	24	87	87	.288	.401	.928	650	204.7	.394	141	190.9
17	Mo Vaughn M. Vaughn	.523	6,410	1,512	5,532	861	1,620	270	10	328	1,064	725	108	1,429	30	18	2,894	608	0	45	144	136	.293	.383	.906	1090	296	.387	129	246.2
18	Prince Fielder P. Fielder	.522	5,790	1,364	4,882	755	1,389	277	10	288	886	751	106	1,004	18	11	2,550	575	0	51	149	125	.285	.388	.910	977	298.5	.386	139	272.2
19	Hal Trosky Sr. H. Trosky Sr.	.522	5,747	1,347	5,161	835	1,561	331	58	228	1,012	545	16	440	28		2,692	617	25			43	.302	.371	.892	992	291.2	.402	126	210.9
20	Willie Stargell W. Stargell	.521	3,116	869	2,719	384	763	147	10	162	545	342	25	677	6	5	1,416	319	0	30	71	45	.281	.363	.883	502	164.4	.387	142	147.6
21	Dan Brouthers D. Brouthers	.518	7,388	1,608	6,441	1,463	2,210	442	196	98	994	822	105	83	256		3,338	736	20				.343	.426	.944	1810	703.6	.437	155	632.9
22	Pete Alonso P. Alonso	.518	3,966	928	3,447	539	871	165	8	244	651	395	96	905	17	4	1,784	417	0	28	44	97	.253	.343	.861	631	155.1	.362	134	165.5
23	Ryan Howard R. Howard	.515	6,530	1,572	5,707	848	1,475	277	21	382	1,194	709	59	1,843	12	5	2,940	680	0	55	154	116	.258	.343	.859	976	212.1	.361	121	175.3
24	Willie McCovey W. McCovey	.513	8,364	2,215	7,040	1,030	1,906	314	39	439	1,345	1,205	53	1,323	20	17	3,615	792	4	62	249	151	.271	.378	.892	1379	478.9	.389	145	432
25	Rafael Palmeiro R. Palmeiro	.513	9,767	2,261	8,472	1,359	2,434	474	29	459	1,480	1,110	74	1,136	78	31	4,343	962	13	98	142	193	.287	.371	.884	1595	418.3	.379	130	367.8