highest run difference in an mlb game in 2021

The Los Angeles Dodgers had the highest run differential by a team in a game in 2021, with a differential of 21 runs versus the Diamondbacks on July 10, 2021.

Interpreted as:

highest run difference in an MLB regular-season game in 2021

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	21	7/10/2021	LAD	vs	ARI	W 22-1	44	22	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
2	Braves	19	5/21/2021	ATL	vs	PIT	W 20-1	41	20	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
3	Braves	18	6/30/2021	ATL	vs	NYM	W 20-2	43	20	20	4	0	4	20	6	1	6	1	1	50	36	8	0	0	0	0	.465	.540	.837	1.377
4	Athletics	17	8/12/2021	OAK	@	CLE	W 17-0	40	17	14	3	0	2	17	10	3	4	0	0	54	23	5	0	1	0	1	.350	.500	.575	1.075
5	Nationals	17	7/19/2021	WSH	vs	MIA	W 18-1	41	18	18	3	1	6	18	2	1	6	0	0	44	41	10	0	0	0	1	.439	.477	1.000	1.477
6	Padres	16	7/16/2021	SDP	@	WSH	W 24-8	50	24	22	3	1	5	23	9	0	7	3	0	60	42	9	1	0	0	0	.440	.525	.840	1.365
7	Blue Jays	15	9/12/2021	TOR	@	BAL	W 22-7	45	22	19	5	0	5	22	8	2	8	0	0	55	39	10	0	0	0	0	.422	.527	.867	1.394
8	Padres	15	5/21/2021	SDP	vs	SEA	W 16-1	40	16	17	2	1	3	16	6	0	8	2	0	46	30	6	0	0	0	1	.425	.500	.750	1.250
9	Giants	15	5/20/2021	SFG	@	CIN	W 19-4	43	19	16	2	0	4	17	6	2	10	0	0	51	30	6	0	0	0	0	.372	.471	.698	1.168
10	Nationals	15	5/14/2021	WSH	@	ARI	W 17-2	51	17	22	6	1	3	17	5	2	5	0	0	59	39	10	1	0	0	0	.431	.500	.765	1.265
11	Astros	14	9/13/2021	HOU	@	TEX	W 15-1	42	15	16	3	0	5	15	5	1	8	0	0	48	34	8	0	0	0	1	.381	.458	.810	1.268
12	Astros	14	8/21/2021	HOU	vs	SEA	W 15-1	38	15	15	5	2	2	14	3	0	5	0	0	42	30	9	0	1	0	0	.395	.429	.789	1.218
13	Red Sox	14	8/14/2021	BOS	vs	BAL	W 16-2	38	16	17	3	1	5	15	4	2	3	0	1	44	37	9	0	0	0	2	.447	.523	.974	1.496
14	Rays	14	7/29/2021	TBR	vs	NYY	W 14-0	36	14	12	2	0	4	13	4	0	14	0	0	41	26	6	0	1	0	0	.333	.390	.722	1.112
15	Tigers	14	7/19/2021	DET	vs	TEX	W 14-0	39	14	19	3	0	1	14	6	1	4	0	0	47	25	4	0	1	0	1	.487	.553	.641	1.194
16	Red Sox	14	7/1/2021	BOS	vs	KCR	W 15-1	38	15	17	3	0	4	14	4	2	9	0	0	45	32	7	0	1	0	2	.447	.511	.842	1.353
17	Blue Jays	14	6/13/2021	TOR	@	BOS	W 18-4	44	18	20	3	0	8	18	4	0	7	1	0	49	47	11	0	1	0	3	.455	.490	1.068	1.558
18	Phillies	14	6/1/2021	PHI	@	CIN	W 17-3	44	17	18	2	0	7	17	6	0	11	1	0	51	41	9	1	0	0	0	.409	.480	.932	1.412
19	Astros	14	4/24/2021	HOU	vs	LAA	W 16-2	42	16	18	7	1	3	14	5	1	7	0	0	48	36	11	0	0	1	2	.429	.500	.857	1.357
20	Blue Jays	14	4/10/2021	TOR	vs	LAA	W 15-1	39	15	14	4	0	0	14	9	0	6	1	0	48	18	4	0	0	0	1	.359	.479	.462	.941
21	Angels	13	9/25/2021	LAA	vs	SEA	W 14-1	37	14	14	1	2	1	14	8	1	8	0	0	46	22	4	0	0	0	1	.378	.500	.595	1.095
22	Cardinals	13	8/28/2021	STL	@	PIT	W 13-0	45	13	18	3	2	1	13	8	0	6	0	0	53	28	6	0	0	1	0	.400	.491	.622	1.113
23	Brewers	13	8/12/2021	MIL	@	CHC	W 17-4	47	17	22	6	1	5	17	4	1	9	1	0	53	45	12	1	0	0	0	.468	.519	.957	1.477
24	Dodgers	13	8/1/2021	LAD	@	ARI	W 13-0	39	13	14	5	0	2	12	7	3	8	0	0	50	25	7	1	0	0	1	.359	.490	.641	1.131
25	Astros	13	6/23/2021	HOU	@	BAL	W 13-0	43	13	17	3	0	4	13	6	0	5	0	1	49	32	7	0	0	0	0	.395	.469	.744	1.214