The Baltimore Orioles had the highest run differential by a team in 1971, with a differential of 212 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	212	1971	158	.639	101	57	5,303	742	1,382	207	25	158	702	672	46	844	66	38	6,143	2,113	390	85	37	69	127	.261	.347	.398	.745
2	Pirates	189	1971	162	.599	97	65	5,674	788	1,555	223	61	154	744	469	29	919	65	31	6,283	2,362	438	62	49	73	120	.274	.330	.416	.746
3	Athletics	127	1971	161	.627	101	60	5,494	691	1,383	195	25	160	642	542	37	1,018	80	53	6,191	2,108	380	80	38	54	113	.252	.321	.384	.705
4	Dodgers	76	1971	162	.549	89	73	5,523	663	1,469	213	38	95	631	489	21	755	76	40	6,155	2,043	346	72	50	62	140	.266	.325	.370	.695
5	Giants	62	1971	162	.556	90	72	5,461	706	1,348	224	36	140	653	654	37	1,042	101	36	6,258	2,064	400	69	37	86	126	.247	.329	.378	.707
6	Tigers	56	1971	162	.562	91	71	5,502	701	1,399	214	38	179	652	540	55	854	35	43	6,196	2,226	431	62	37	70	129	.254	.325	.405	.730
7	Cardinals	40	1971	163	.556	90	72	5,610	739	1,542	225	54	95	686	543	25	757	124	53	6,300	2,160	374	63	59	67	139	.275	.338	.385	.723
8	Mets	38	1971	162	.512	83	79	5,477	588	1,365	203	29	98	546	547	28	958	89	43	6,178	1,920	330	91	35	59	147	.249	.319	.351	.669
9	Royals	37	1971	161	.528	85	76	5,295	603	1,323	225	40	80	573	490	25	819	130	46	5,914	1,868	345	45	59	54	128	.250	.313	.353	.666
10	Red Sox	24	1971	162	.525	85	77	5,401	691	1,360	246	28	161	650	552	32	871	51	34	6,107	2,145	435	75	47	46	146	.252	.322	.397	.719
11	White Sox	20	1971	162	.488	79	83	5,382	617	1,346	185	30	138	568	562	51	870	83	65	6,114	2,005	353	81	38	45	105	.250	.325	.373	.697
12	Astros	18	1971	162	.488	79	83	5,492	585	1,319	230	52	71	547	478	29	888	101	51	6,105	1,866	353	65	41	44	105	.240	.302	.340	.642
13	Yankees	7	1971	162	.506	82	80	5,413	648	1,377	195	43	97	607	581	37	717	75	55	6,164	1,949	335	77	56	58	140	.254	.328	.360	.688
14	Reds	5	1971	162	.488	79	83	5,414	586	1,306	203	28	138	542	438	27	907	59	33	5,973	1,979	369	69	25	52	138	.241	.300	.366	.665
15	Cubs	-11	1971	162	.512	83	79	5,438	637	1,401	202	34	128	603	527	34	772	44	32	6,131	2,055	364	92	40	65	144	.258	.325	.378	.703
16	Twins	-16	1971	160	.463	74	86	5,414	654	1,406	197	31	116	618	512	25	846	66	44	6,072	2,013	344	64	57	61	158	.260	.323	.372	.695
17	Braves	-56	1971	162	.506	82	80	5,575	643	1,434	192	30	153	597	434	28	747	57	46	6,172	2,145	375	91	44	72	120	.257	.312	.385	.697
18	Angels	-65	1971	162	.469	76	86	5,495	511	1,271	213	18	96	476	441	29	827	72	34	6,079	1,808	327	83	31	61	141	.231	.290	.329	.619
19	Brewers	-75	1971	161	.429	69	92	5,185	534	1,188	160	23	104	496	543	30	924	82	53	5,904	1,706	287	107	39	40	103	.229	.304	.329	.633
20	Expos	-107	1971	162	.441	71	90	5,335	622	1,312	197	29	88	567	543	78	800	51	43	6,098	1,831	314	102	40	58	136	.246	.322	.343	.666
21	Senators	-123	1971	159	.396	63	96	5,290	537	1,219	189	30	86	501	575	28	956	68	45	5,986	1,726	305	58	35	58	127	.230	.307	.326	.634
22	Padres	-124	1971	161	.379	61	100	5,366	486	1,250	184	31	96	447	438	25	966	70	45	5,935	1,784	311	87	19	42	134	.233	.293	.332	.625
23	Phillies	-130	1971	162	.414	67	95	5,538	558	1,289	209	35	123	522	499	34	1,031	63	39	6,171	1,937	367	55	45	56	98	.233	.298	.350	.648
24	Indians	-204	1971	162	.370	60	102	5,467	543	1,303	200	20	109	507	467	31	868	57	37	6,061	1,870	329	67	29	44	127	.238	.300	.342	.643