The Pittsburgh Pirates had the highest run differential by a team in 1972, with a differential of 179 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	179	1972	155	.619	96	59	5,490	691	1,505	251	47	110	654	404	25	871	49	30	6,021	2,180	408	52	50	69	110	.274	.324	.397	.721
2	Reds	150	1972	154	.617	95	59	5,241	707	1,317	214	44	124	650	606	37	914	140	63	6,003	1,991	382	65	54	85	109	.251	.330	.380	.710
3	Athletics	147	1972	155	.600	93	62	5,200	604	1,248	195	29	134	565	463	47	886	87	48	5,846	1,903	358	100	36	55	112	.240	.306	.366	.672
4	Cubs	118	1972	156	.548	85	70	5,247	685	1,346	206	40	133	634	565	28	815	69	47	5,950	2,031	379	67	43	78	126	.257	.330	.387	.717
5	Orioles	89	1972	154	.519	80	74	5,028	519	1,153	193	29	100	483	507	36	935	78	41	5,676	1,704	322	65	40	57	113	.229	.302	.339	.641
6	Astros	72	1972	153	.549	84	69	5,267	708	1,359	233	38	134	660	524	32	907	111	56	5,936	2,070	405	62	51	69	98	.258	.326	.393	.719
7	Dodgers	57	1972	155	.548	85	70	5,270	584	1,349	178	39	98	543	480	24	786	82	39	5,903	1,899	315	89	40	53	121	.256	.319	.360	.679
8	Tigers	44	1972	156	.551	86	70	5,099	558	1,206	179	32	122	531	483	31	793	17	21	5,721	1,815	333	74	34	65	125	.237	.305	.356	.661
9	Royals	35	1972	154	.494	76	78	5,167	580	1,317	220	26	78	547	534	34	711	85	44	5,845	1,823	324	72	38	57	134	.255	.327	.353	.679
10	Yankees	30	1972	155	.510	79	76	5,168	557	1,288	202	24	103	526	491	29	689	71	42	5,793	1,847	329	74	31	47	112	.249	.316	.357	.674
11	White Sox	28	1972	154	.565	87	67	5,083	566	1,208	170	28	108	528	511	34	991	100	52	5,721	1,758	306	68	25	69	113	.238	.310	.346	.656
12	Red Sox	20	1972	155	.548	85	70	5,208	640	1,289	229	34	124	594	522	37	858	66	30	5,871	1,958	387	56	48	49	111	.248	.318	.376	.694
13	Giants	13	1972	155	.445	69	86	5,245	662	1,281	211	36	150	600	480	30	964	123	45	5,858	2,014	397	64	39	42	107	.244	.309	.384	.693
14	Twins	2	1972	154	.500	77	77	5,234	537	1,277	182	31	93	506	478	35	905	53	41	5,848	1,800	306	73	28	53	129	.244	.310	.344	.654
15	Cardinals	-32	1972	156	.481	75	81	5,326	568	1,383	214	42	70	518	437	27	793	104	48	5,884	1,891	326	58	36	61	141	.260	.317	.355	.672
16	Indians	-47	1972	156	.462	72	84	5,207	472	1,220	186	18	91	440	420	26	762	49	53	5,769	1,715	295	83	33	62	112	.234	.293	.329	.622
17	Mets	-50	1972	156	.532	83	73	5,135	528	1,154	175	31	105	490	589	34	990	41	41	5,883	1,706	311	86	39	70	127	.225	.307	.332	.639
18	Angels	-79	1972	155	.484	75	80	5,165	454	1,249	171	26	78	420	358	25	850	57	37	5,639	1,706	275	66	25	52	125	.242	.293	.330	.623
19	Expos	-96	1972	156	.449	70	86	5,156	513	1,205	156	22	91	462	474	49	828	68	66	5,817	1,678	269	108	30	55	96	.234	.303	.325	.628
20	Braves	-102	1972	155	.455	70	84	5,278	628	1,363	186	17	144	593	532	35	770	47	35	5,938	2,015	347	55	38	44	131	.258	.328	.382	.710
21	Brewers	-102	1972	156	.417	65	91	5,124	493	1,204	167	22	88	461	472	29	868	64	57	5,733	1,679	277	78	30	42	144	.235	.302	.328	.629
22	Phillies	-132	1972	156	.378	59	97	5,248	503	1,240	200	36	98	469	487	22	930	42	50	5,862	1,806	334	69	36	50	104	.236	.302	.344	.646
23	Rangers	-167	1972	154	.351	54	100	5,029	461	1,092	166	17	56	424	503	30	926	126	73	5,680	1,460	239	84	34	41	100	.217	.290	.290	.581
24	Padres	-177	1972	153	.379	58	95	5,213	488	1,181	168	38	102	452	407	15	976	78	46	5,750	1,731	308	90	25	53	97	.227	.283	.332	.615