The Arizona Diamondbacks and the Boston Red Sox were tied for the highest run differential in a game in 2024, with a differential of 17 runs.

Interpreted as:

highest run differential in a regular-season game 2024

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Diamondbacks	17	7/30/2024	ARI	vs	WSH	W 17-0	45	17	22	6	0	3	17	3	0	3	1	0	49	37	9	0	1	0	0	.489	.510	.822	1.332
2	Red Sox	17	4/27/2024	BOS	vs	CHC	W 17-0	43	17	21	6	0	2	17	2	2	6	1	0	49	33	8	1	1	0	0	.488	.521	.767	1.288
3	Dodgers	16	9/19/2024	LAD	@	MIA	W 20-4	39	20	16	3	0	3	19	10	2	6	4	0	53	28	6	0	2	0	0	.410	.528	.718	1.246
4	Athletics	16	5/4/2024	OAK	vs	MIA	W 20-4	45	20	21	1	1	6	20	6	3	3	0	0	54	42	8	0	0	0	1	.467	.556	.933	1.489
5	Diamondbacks	16	4/19/2024	ARI	@	SFG	W 17-1	48	17	22	6	0	1	16	5	0	5	0	0	53	31	7	0	0	0	1	.458	.509	.646	1.155
6	Blue Jays	15	8/31/2024	TOR	@	MIN	W 15-0	48	15	23	4	1	4	15	4	1	9	0	0	53	41	9	0	0	0	2	.479	.528	.854	1.382
7	Athletics	15	7/14/2024	OAK	@	PHI	W 18-3	40	18	15	2	1	8	18	5	0	5	0	1	46	43	11	0	1	0	0	.375	.435	1.075	1.510
8	Diamondbacks	15	3/28/2024	ARI	vs	COL	W 16-1	40	16	18	3	0	1	16	3	0	9	0	0	44	24	4	0	1	0	1	.450	.477	.600	1.077
9	Phillies	14	9/6/2024	PHI	@	MIA	W 16-2	48	16	22	8	0	2	16	2	1	9	0	0	53	36	10	0	2	0	1	.458	.472	.750	1.222
10	Brewers	14	8/30/2024	MIL	@	CIN	W 14-0	41	14	15	3	1	4	14	7	0	12	4	0	49	32	8	0	1	0	0	.366	.449	.780	1.229
11	Tigers	14	8/13/2024	DET	vs	SEA	W 15-1	44	15	20	5	0	5	15	1	0	6	1	0	45	40	10	0	0	0	0	.455	.467	.909	1.376
12	Mariners	13	9/4/2024	SEA	@	OAK	W 16-3	42	16	16	7	0	1	16	4	1	6	1	0	48	26	8	0	1	0	0	.381	.438	.619	1.057
13	Cubs	13	9/1/2024	CHC	@	WSH	W 14-1	45	14	17	4	0	0	12	4	0	11	0	0	49	21	4	0	0	0	1	.378	.429	.467	.895
14	Mets	13	7/29/2024	NYM	vs	MIN	W 15-2	38	15	17	4	0	1	15	7	1	5	1	0	49	24	5	0	3	0	0	.447	.510	.632	1.142
15	Rays	13	7/25/2024	TBR	@	TOR	W 13-0	42	13	16	5	0	1	13	6	2	8	2	0	51	24	6	0	1	0	0	.381	.471	.571	1.042
16	Rockies	13	7/24/2024	COL	vs	BOS	W 20-7	45	20	21	4	0	4	20	2	1	10	0	0	50	37	8	0	2	0	0	.467	.480	.822	1.302
17	Dodgers	13	6/11/2024	LAD	vs	TEX	W 15-2	35	15	14	1	0	5	15	8	2	3	1	0	46	30	6	0	1	0	1	.400	.522	.857	1.379
18	Tigers	13	5/17/2024	DET	@	ARI	W 13-0	44	13	17	5	2	0	13	2	1	11	0	0	47	26	7	0	0	0	0	.386	.426	.591	1.016
19	Diamondbacks	13	4/23/2024	ARI	@	STL	W 14-1	41	14	15	4	0	3	14	4	1	10	0	0	46	28	7	0	0	0	1	.366	.435	.683	1.118
20	Braves	12	9/19/2024	ATL	@	CIN	W 15-3	43	15	18	1	0	6	15	3	2	10	0	0	48	37	7	0	0	0	2	.419	.479	.860	1.340
21	Braves	12	9/10/2024	ATL	@	WSH	W 12-0	42	12	15	3	0	4	12	4	2	8	1	0	48	30	7	0	0	0	1	.357	.438	.714	1.152
22	Cubs	12	9/4/2024	CHC	vs	PIT	W 12-0	39	12	17	3	0	3	11	3	1	6	0	0	43	29	6	0	0	0	0	.436	.488	.744	1.232
23	Cubs	12	8/24/2024	CHC	@	MIA	W 14-2	43	14	17	5	1	4	12	8	2	7	0	0	53	36	10	0	0	1	1	.395	.509	.837	1.347
24	Royals	12	8/17/2024	KCR	@	CIN	W 13-1	43	13	15	4	0	2	12	6	0	7	0	0	51	25	6	0	2	0	0	.349	.412	.581	.993
25	Pirates	12	7/5/2024	PIT	vs	NYM	W 14-2	37	14	16	1	0	7	14	5	1	4	0	0	43	38	8	0	0	0	1	.432	.512	1.027	1.539