The Chicago Cubs have the highest run differential by a team in wins this season, with a differential of 201 runs.

Interpreted as:

highest run differential in wins this regular season

	TEAM	DIFF	W	SEASON	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	201	46	2025	0	1.000	46	1,635	333	478	94	13	88	328	181	16	344	71	8	1,856	862	195	5	19	7	20	.292	.365	.527	.892
2	Tigers	193	48	2025	0	1.000	48	1,654	309	478	89	8	71	297	162	27	389	18	5	1,864	796	168	3	18	4	29	.289	.358	.481	.840
3	Yankees	192	44	2025	0	1.000	44	1,519	297	440	96	8	83	288	192	23	363	35	12	1,756	801	187	2	20	15	24	.290	.373	.527	.901
4	Dodgers	179	47	2025	0	1.000	47	1,625	338	475	90	12	87	325	206	21	357	29	8	1,878	850	189	2	24	15	32	.292	.374	.523	.897
5	Brewers	178	42	2025	0	1.000	42	1,413	274	397	74	5	52	258	161	13	302	64	14	1,622	637	131	15	20	10	22	.281	.355	.451	.806
6	Rays	168	43	2025	0	1.000	43	1,500	297	440	85	4	63	280	154	17	358	72	10	1,688	722	152	4	13	3	21	.293	.363	.481	.844
7	Reds	162	39	2025	0	1.000	39	1,324	261	388	73	3	64	252	160	15	312	32	11	1,518	659	140	5	14	7	27	.293	.372	.498	.870
8	Astros	153	44	2025	0	1.000	44	1,490	246	426	74	6	59	235	140	23	316	29	15	1,672	689	139	6	13	6	40	.286	.354	.462	.816
9	Cardinals	151	42	2025	0	1.000	42	1,422	261	399	82	4	52	247	153	26	310	25	10	1,625	645	138	6	18	8	22	.281	.357	.454	.811
10	Mets	150	45	2025	0	1.000	45	1,516	253	417	91	11	73	246	149	31	332	43	8	1,714	749	175	1	17	9	39	.275	.349	.494	.843
11	Phillies	149	46	2025	0	1.000	46	1,573	275	452	83	8	62	261	180	20	332	46	11	1,794	737	153	7	14	5	31	.287	.365	.469	.833
12	Rangers	143	38	2025	0	1.000	38	1,260	211	340	65	3	55	200	137	17	266	36	5	1,430	576	123	1	15	5	26	.270	.346	.457	.803
13	Twins	141	37	2025	0	1.000	37	1,284	229	366	70	5	55	219	129	25	290	20	7	1,448	611	130	1	9	4	22	.285	.359	.476	.835
14	Red Sox	141	40	2025	0	1.000	40	1,392	257	395	91	6	68	246	150	15	326	33	12	1,569	702	165	4	8	7	21	.284	.358	.504	.862
15	Padres	134	40	2025	0	1.000	40	1,346	221	376	70	5	46	204	144	12	276	35	8	1,528	594	121	13	13	5	24	.279	.351	.441	.792
16	Blue Jays	133	41	2025	0	1.000	41	1,419	241	423	80	2	54	231	126	17	232	22	8	1,593	669	136	13	18	8	25	.298	.358	.471	.830
17	Mariners	131	38	2025	0	1.000	38	1,312	228	353	67	1	64	222	152	19	324	37	10	1,501	614	132	8	10	4	17	.269	.351	.468	.819
18	Braves	126	35	2025	0	1.000	35	1,217	211	350	57	3	48	203	135	12	261	21	6	1,382	557	108	6	12	6	27	.288	.361	.458	.819
19	Diamondbacks	121	38	2025	0	1.000	38	1,273	242	356	79	9	66	239	165	16	283	43	11	1,488	651	154	11	23	7	23	.280	.364	.511	.875
20	Giants	116	43	2025	0	1.000	43	1,409	237	352	74	11	50	223	170	13	361	30	11	1,618	598	135	9	17	4	21	.250	.333	.424	.757
21	Athletics	113	32	2025	0	1.000	32	1,144	187	335	59	5	51	179	88	8	253	19	6	1,248	557	115	2	6	2	23	.293	.346	.487	.833
22	Orioles	113	33	2025	0	1.000	33	1,101	187	305	50	6	53	179	105	15	265	28	10	1,233	526	109	2	10	5	28	.277	.345	.478	.823
23	Guardians	110	37	2025	0	1.000	37	1,225	198	321	62	7	47	187	134	18	297	36	8	1,403	538	116	6	20	8	21	.262	.339	.439	.778
24	Royals	106	38	2025	0	1.000	38	1,302	187	376	78	6	39	187	96	10	227	42	15	1,436	583	123	13	15	8	19	.289	.339	.448	.786
25	White Sox	104	24	2025	0	1.000	24	785	148	208	50	2	29	144	105	6	192	25	3	912	349	81	7	9	2	7	.265	.352	.445	.797