The New York Yankees have the highest run differential by a team, with a differential of 13,208 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,208	19,176	.570	10,872	8,216	653,521	93,216	173,428	28,805	5,507	17,515	86,637	69,038	4,959	95,884	11,751	2,828	740,439	265,792	51,827	9,601	3,320	2,869	10,758	.265	.339	.407	.745
2	Giants	7,455	21,885	.535	11,622	10,100	746,809	101,156	196,327	31,514	7,058	15,711	90,606	68,690	5,728	100,551	16,559	3,158	835,962	289,090	54,283	11,680	3,055	4,028	10,258	.263	.328	.387	.716
3	Dodgers	6,324	21,801	.532	11,525	10,137	742,799	98,469	194,023	31,233	7,018	14,299	88,666	69,302	5,189	101,309	17,397	3,566	833,248	282,189	52,550	12,784	3,098	3,759	10,016	.261	.327	.380	.707
4	Red Sox	3,687	19,463	.518	10,044	9,336	666,123	90,918	177,700	33,354	5,616	14,729	84,326	67,162	4,856	96,544	9,724	2,577	752,116	266,473	53,699	10,605	3,370	3,011	11,624	.267	.337	.400	.737
5	Cubs	3,665	22,417	.513	11,419	10,837	767,068	103,213	200,830	33,933	7,376	15,407	88,784	68,943	5,317	105,949	15,893	3,095	857,306	295,736	56,716	13,031	2,947	3,531	10,014	.262	.326	.386	.711
6	Guardians	2,257	19,474	.513	9,940	9,443	663,602	87,976	175,517	31,326	5,512	14,035	81,330	62,968	4,877	95,572	12,004	3,410	746,317	259,972	50,873	11,484	3,386	2,569	10,578	.264	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,862	20,768	.513	10,583	10,054	710,288	92,873	188,651	32,002	7,057	12,963	84,911	64,506	5,267	99,109	15,072	3,632	795,221	273,656	52,022	11,993	3,167	3,784	10,213	.266	.330	.385	.715
9	Braves	1,515	22,379	.503	11,190	11,035	766,192	100,041	198,936	32,285	6,314	15,195	87,073	67,915	5,104	101,117	14,149	3,083	854,811	289,434	53,794	12,694	2,906	3,665	10,451	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	771	22,001	.504	11,017	10,845	749,591	98,706	195,242	32,553	7,577	14,439	87,820	67,066	5,539	103,263	18,219	3,421	838,107	286,266	54,569	12,671	3,072	3,657	9,796	.260	.325	.382	.707
13	Astros	727	10,141	.503	5,096	5,040	344,176	43,252	87,719	16,086	2,179	8,563	40,713	32,676	2,951	63,857	7,210	3,151	386,581	133,852	26,828	4,038	2,740	3,154	7,496	.255	.322	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	463	7,714	.500	3,855	3,856	264,282	35,737	68,775	13,744	1,503	8,407	33,909	24,510	2,472	49,724	4,621	1,979	294,945	110,746	23,654	1,526	2,155	1,418	6,026	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	323	19,498	.503	9,763	9,642	664,850	89,528	175,573	29,761	6,324	14,718	82,459	65,897	4,491	97,755	11,333	2,949	749,392	262,136	50,803	11,010	3,144	2,455	10,776	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331